Leiden University Medical Center, Leiden, the Netherlands.
National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Obesity (Silver Spring). 2021 Nov;29(11):1925-1938. doi: 10.1002/oby.23260. Epub 2021 Sep 13.
Obesity is becoming a global public health problem, but it is unclear how it impacts different generations over the life course. Here, a descriptive analysis of the age-related changes in anthropometric measures and related cardiometabolic risk factors across different generations was performed.
The development of anthropometric measures and related cardiometabolic risk factors was studied during 26 years of follow-up in the Doetinchem Cohort Study (N = 6,314 at baseline). All analyses were stratified by sex and generation, i.e., 10-year age groups (20-29, 30-39, 40-49, and 50-59 years) at baseline. Generalized estimating equations were used to test for generational differences.
Weight, BMI, waist circumference, and prevalence of overweight and obesity were higher, in general, in the younger generations during the first 10 to 15 years of follow-up. From age 50 to 59 years onward, these measures converged in all generations of men and women. Among cardiometabolic risk factors, only type 2 diabetes showed an unfavorable shift between the two oldest generations of men.
It was observed that, compared with the older generations, the younger generations had obesity at an earlier age but did not reach higher levels at midlife and beyond. This increased exposure to obesity was not (yet) associated with increased prevalence of cardiometabolic risk factors.
肥胖正在成为一个全球性的公共卫生问题，但目前尚不清楚它如何在整个生命周期中影响不同的世代。在这里，我们对不同世代的人体测量指标和相关心血管代谢危险因素的年龄相关变化进行了描述性分析。
在多廷赫姆队列研究（基线时共有 6314 人）26 年的随访中，研究了人体测量指标和相关心血管代谢危险因素的发展情况。所有分析均按性别和世代分层，即基线时的 10 岁年龄组（20-29、30-39、40-49 和 50-59 岁）。使用广义估计方程来检验世代差异。
一般来说，在随访的前 10-15 年，年轻一代的体重、BMI、腰围以及超重和肥胖的患病率普遍较高。从 50 岁到 59 岁，所有男性和女性世代的这些指标都趋于一致。在心血管代谢危险因素中，只有 2 型糖尿病在男性的两个最年长世代之间显示出不利的转变。
与老一代相比，年轻一代更早出现肥胖，但在中年及以后并没有达到更高的水平。这种接触肥胖的增加与心血管代谢危险因素的患病率增加无关。
