The California Institute for Regenerative Medicine, Oakland, California, USA.
Stem Cells Transl Med. 2021 Dec;10(12):1581-1587. doi: 10.1002/sctm.21-0239. Epub 2021 Sep 13.
Debilitating diseases of the eye represent a large unmet medical need potentially addressable with stem cell-based approaches. Over the past decade, the California Institute for Regenerative Medicine (CIRM) has funded and supported the translation, from early research concepts to human trials, of therapeutic stem cell approaches for dry age-related macular degeneration, retinitis pigmentosa, and limbal stem cell deficiency. This article chronicles CIRM's journey in the ophthalmology field and discusses some key challenges and questions that were addressed along the way as well as questions that remain.
致盲性眼病是大量未被满足的医疗需求，而基于干细胞的方法可能为其提供治疗途径。在过去十年中，加利福尼亚再生医学研究所（CIRM）资助并支持了将干性年龄相关性黄斑变性、视网膜色素变性和角膜缘干细胞缺乏症的治疗性干细胞方法从早期研究概念转化为人体试验的工作。本文记录了 CIRM 在眼科领域的探索历程，并讨论了在这一过程中遇到的一些关键挑战和问题，以及仍然存在的问题。
