Ophthalmology. 1978 Jan;85(1):82-106. doi: 10.1016/s0161-6420(78)35693-1.
Data from the Diabetic Retinopathy Study (DRS) show that photocoagulad inhibited the progression of retinopathy. These beneficial effects were noted to some degree in all those stages of diabetic retinopathy which were included in the Study. Some deleterious effects of treatment were also found, including losses of visual acuity and constriction of peripheral visual field. The risk of these harmful effects was considered acceptable in eyes with retinopathy in the moderate or severe retinopathy in the moderate or severe proliferative stage when the risk of severe visual loss without treatment was great. In early proliferative or severe nonproliferative retinopathy, when the risk of severe visual loss without treatment was less, the risks of harmful treatment effects assumed greater importance. In these earlier stages, DRS findings have not led to a clear choice between prompt treatment and deferral of treatment unless and until progression to a more severe stage occurs.
糖尿病视网膜病变研究（DRS）的数据表明，光凝治疗可抑制视网膜病变的进展。在该研究纳入的糖尿病视网膜病变的所有阶段，均在一定程度上观察到了这些有益效果。同时也发现了治疗的一些有害影响，包括视力丧失和周边视野缩窄。当不进行治疗时严重视力丧失的风险很高时，对于中度或重度增殖期视网膜病变的眼睛，这些有害影响的风险被认为是可以接受的。在早期增殖性或严重非增殖性视网膜病变中，当不进行治疗时严重视力丧失的风险较低时，有害治疗效果的风险就显得更为重要。在这些早期阶段，除非病情进展到更严重的阶段，DRS的研究结果并未导致在立即治疗和延迟治疗之间做出明确选择。
