Koerner F, Schlegel D, Koerner U
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Aug 30;200(2):99-1111. doi: 10.1007/BF00414359.
Preliminary results of a controlled study on diabetic retinopathy are reported. Two hundred and fifteen patients with proliferative (PDR) and nonproliferative (NPDR) retinopathy were uniocularly treated by Xenon photocoagulation and followed for a minimum of 6 months--6 years. Intra- and epiretinal new vessel formations (RNF) decreased in treated but increased in untreated eyes at a high statistical significance. A transition of background retinopathy into the proliferative stage was significantly retarded after photocoagulation. An improvement of new vessel formations on the disc (DNF) was not evident after 3 years of follow-up. The progression of preretinal neovascularization (PRNF) was significantly reduced only for 1--2 years after treatment. The incidence of massive vitreous hemorrhages, however, which showed the highest quotient of contingency with PRNF was much lower in treated eyes also after 3 years. The difference was significant only in extensively photocoagulated eyes with more than 100 lesions on average. The effect of photocoagulation on diabetic maculopathy with preservation of a useful visual acuity was highly significant only in diabetics under 60 years of age, the effect increasing with time as the control eyes fared worse. By contrast, in patients over 60 years of age, the course of maculpathy was not influenced, and a linear decrease of visual acuity occurred in both treated and untreated eyes.
本文报告了一项关于糖尿病性视网膜病变的对照研究的初步结果。215例增殖性（PDR）和非增殖性（NPDR）视网膜病变患者单眼接受氙光凝治疗，并随访至少6个月至6年。治疗眼的视网膜内和视网膜前新生血管形成（RNF）减少，而未治疗眼的则增加，具有高度统计学意义。光凝后，背景性视网膜病变向增殖期的转变明显延迟。随访3年后，视盘新生血管形成（DNF）的改善并不明显。治疗后仅1至2年，视网膜前新生血管形成（PRNF）的进展显著降低。然而，与PRNF相关性最高的大量玻璃体积血的发生率，在治疗眼3年后也低得多。仅在平均有100多个病灶的广泛光凝眼中，差异才有统计学意义。光凝对保留有用视力的糖尿病性黄斑病变的效果，仅在60岁以下的糖尿病患者中具有高度统计学意义，随着时间的推移效果增强，因为对照眼情况更差。相比之下，在60岁以上的患者中，黄斑病变的病程未受影响，治疗眼和未治疗眼的视力均呈线性下降。
