Von Graffenried Beat, Adler Rolf, Abt Klaus, Nüesch Erich, Spiegel René
(B.v.G., E.N. and R.S.) Experimental Therapeutics, Biological and Medical Research, Pharmaceutical Division, Sandoz Ltd., CH-4002 BasleSwitzerland (R.A.) Medical Faculty of the University of Berne, Department of Medicine, University of Berne, CH-3000 BerneSwitzerland (K.A.) Department of Biostatistics, J.W. Goethe University, D-6 Frankfurt am Main 70 G.F.R.
Pain. 1978 Feb;4(3):253-263. doi: 10.1016/0304-3959(77)90137-3.
A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man. In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined: (a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo, (b) practice effect, (c) initial pain sensitivity, (d) anxiety, coping behaviour, attitude to the experiment and personality factors. The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner.
对一些可能导致人体实验性疼痛结果不可靠的因素进行了研究。在一项针对32名健康男性志愿者的随机、双盲、交叉研究中，进行了缺血性疼痛测试[14]和多项心理测试。研究了以下因素对疼痛测试结果的影响：(a)口服单剂量1000毫克阿司匹林（ASA）和安慰剂，(b)练习效应，(c)初始疼痛敏感性，(d)焦虑、应对行为、对实验的态度和人格因素。未证明ASA具有镇痛活性。发现初始疼痛敏感性与给药顺序之间存在相互作用。此外，焦虑对测试结果有显著影响。由于焦虑在个体内和个体间以不可预测和不可控制的方式波动，因此使用实验性疼痛模型无法获得可靠的结果。
