Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Br J Sports Med. 2022 Aug;56(15):847-853. doi: 10.1136/bjsports-2021-104231. Epub 2021 Sep 14.
To determine the association between moderate-to-vigorous intensity physical activity (MVPA) trajectories (course over age and time) through the adult life course and onset of metabolic disease (diabetes and dyslipidaemia).
We analysed prospective community-based cohort data of 5115 participants in the Coronary Artery Risk Development in Young Adults study, who were black and white men and women aged 18-30 years at baseline (1985-1986) at four urban sites, collected through 30 years of follow-up. Individualised MVPA trajectories were developed for each participant using linear mixed models.
Lower estimated MVPA score at age 18 was associated with a 12% (95% CI 6% to 18%) higher odds of incident diabetes, a 4% (95% CI 1% to 7%) higher odds of incident low high-density lipoprotein (HDL) and a 6% (95% CI 2% to 11%) higher odds of incident high triglycerides. Each additional annual 1-unit reduction in the MVPA score was associated with a 6% (95% CI 4% to 9%) higher annual odds of diabetes incidence and a 4% (95% CI 2% to 6%) higher annual odds of high triglyceride incidence. Analysing various MVPA trajectory groups, participants who were in the most active group at age 18 (over 300 min/week), but with sharp declines in midlife, had higher odds of high low-density lipoprotein and low HDL incidence, compared with those in the most active group at age 18 with subsequent gains.
Given recent trends in declining MVPA across the life course and associated metabolic disease risk, young adulthood is an important time period for interventions to increase and begin the maintenance of MVPA.
通过成人生命历程中中等至剧烈强度体力活动（MVPA）轨迹（随年龄和时间的变化），确定其与代谢疾病（糖尿病和血脂异常）发病之间的关联。
我们分析了冠状动脉风险发展在年轻人研究中的前瞻性社区队列数据，该研究共有 5115 名参与者，均为黑人及白人男性和女性，基线年龄为 18-30 岁（1985-1986 年），在四个城市地点招募，通过 30 年的随访收集数据。使用线性混合模型为每个参与者制定个体化 MVPA 轨迹。
18 岁时较低的 MVPA 估计得分与糖尿病发病风险增加 12%（95%CI 6%至 18%）、低高密度脂蛋白（HDL）发病风险增加 4%（95%CI 1%至 7%）和高甘油三酯发病风险增加 6%（95%CI 2%至 11%）相关。MVPA 得分每年减少 1 个单位，与糖尿病发病风险每年增加 6%（95%CI 4%至 9%）和高甘油三酯发病风险每年增加 4%（95%CI 2%至 6%）相关。分析各种 MVPA 轨迹组，18 岁时处于最活跃组（每周超过 300 分钟）的参与者，但在中年时急剧下降，与 18 岁时处于最活跃组但随后逐渐增加的参与者相比，其发生高低密度脂蛋白和低 HDL 的几率更高。
鉴于生命历程中 MVPA 呈下降趋势以及相关代谢疾病风险增加，青年期是增加和开始维持 MVPA 的重要时期，应采取干预措施。
