Munuswamy Revathy, De Brandt Jana, Burtin Chris, Derave Wim, Aumann Joseph, Spruit Martijn A, Michiels Luc
Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium.
Faculty of Rehabilitation Sciences, Rehabilitation Research Center REVAL, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium.
J Inflamm Res. 2021 Sep 7;14:4503-4507. doi: 10.2147/JIR.S320659. eCollection 2021.
Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.
慢性阻塞性肺疾病（COPD）患者常出现慢性低度全身炎症，例如五聚体CRP（pCRP）升高。然而，pCRP可解离形成单体CRP（mCRP），与pCRP更多的抗炎特性相比，mCRP表现出明显的促炎行为。因此，mCRP可能是一种可反映慢性低度全身炎症的信息性生物标志物。对38例COPD患者和18名非COPD对照者（NCCP）的血清样本进行分析证实了这一点。与NCCP相比，COPD患者的mCRP显著升高，表明mCRP可被视为慢性低度全身炎症的一种新的敏感标志物。
