[植物名称]叶提取物对多种致病细菌的抗菌活性评估。 （注：原文中“of”后面缺少具体植物名称）
Evaluation of the Antimicrobial Activity of Leaf Extracts of against Various Disease-Causing Bacteria.
作者信息
Kenubih Ambaye, Belay Eyerusalem, Lemma Kumneger
机构信息
University of Gondar, College of Veterinary Medicine and Animal Sciences, Gondar, Ethiopia.
出版信息
J Exp Pharmacol. 2021 Sep 7;13:889-899. doi: 10.2147/JEP.S322396. eCollection 2021.
BACKGROUND
In traditional medicine of Ethiopia, is the one used to treat different infectious diseases. Hence, this study was conducted with the main aim of determining active compounds in the leaves of .
METHODS
The antimicrobial activities of using disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and acute oral toxicity of the fraction.
RESULTS
The average bacterial zone of inhibition of the dichloromethane (DCM), chloroform (TCM), petroleum ether (PE) and ethyl acetate (EA) fractions ranged from 7.67 mm to 18.12 mm. The average values of MIC of the DCM, TCM, PE and EA fractions ranged from 4.17 mg/mL to 33.34 mg/mL. The most susceptible bacterium at 200 mg/mL was , (18.12mm), while the less susceptible bacterium was (14.33mm).
CONCLUSION
The solvent fractions demonstrated significant antibacterial activities with varying spectrum and safe up to 2000mg/kg.
背景
在埃塞俄比亚的传统医学中，[植物名称缺失]被用于治疗不同的传染病。因此，本研究的主要目的是确定[植物名称缺失]叶子中的活性成分。
方法
采用纸片扩散法、最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测定[植物名称缺失]的抗菌活性，并测定该提取物的急性经口毒性。
结果
二氯甲烷（DCM）、氯仿（TCM）、石油醚（PE）和乙酸乙酯（EA）提取物的平均抑菌圈直径在7.67毫米至18.12毫米之间。DCM、TCM、PE和EA提取物的MIC平均值在4.17毫克/毫升至33.34毫克/毫升之间。在200毫克/毫升时，最敏感的细菌是[细菌名称缺失]（18.12毫米），而最不敏感的细菌是[细菌名称缺失]（14.33毫米）。
结论
溶剂提取物表现出显著的抗菌活性，抗菌谱各异，且在高达2000毫克/千克的剂量下是安全的。
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