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心力衰竭中的钾缺乏及其与利尿剂长期治疗的关系:文献综述

Potassium depletion in heart failure and its relation to long-term treatment with diuretics: a review of the literature.

作者信息

Morgan D B, Burkinshaw L, Davidson C

出版信息

Postgrad Med J. 1978 Feb;54(628):72-9. doi: 10.1136/pgmj.54.628.72.

DOI:10.1136/pgmj.54.628.72
PMID:345254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425062/
Abstract

There have been many studies which suggest that patients with heart failure were potassium depleted. This depletion has been attributed to the use of potent diuretics, and these are now given with either potassium supplements or potassium-retaining diuretics. A detailed examination of the studies suggests that the reported decrease in body potassium compared with the results in healthy persons is not due to the diuretics. It can be partly explained by a failure to match patients and controls in terms of age, and the remaining difference can be explained by muscle wasting. There is therefore no evidence of a potassium depletion in these patients with heart failure.

摘要

有许多研究表明,心力衰竭患者存在钾缺乏。这种缺乏归因于强效利尿剂的使用,现在使用这些利尿剂时会同时给予钾补充剂或保钾利尿剂。对这些研究的详细检查表明,与健康人相比,报告的身体钾含量下降并非由于利尿剂。部分原因可以解释为在年龄方面未能使患者和对照组相匹配,其余差异可以用肌肉萎缩来解释。因此,没有证据表明这些心力衰竭患者存在钾缺乏。

相似文献

1
Potassium depletion in heart failure and its relation to long-term treatment with diuretics: a review of the literature.心力衰竭中的钾缺乏及其与利尿剂长期治疗的关系:文献综述
Postgrad Med J. 1978 Feb;54(628):72-9. doi: 10.1136/pgmj.54.628.72.
2
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Cardiac arrhythmias induced by hypokalaemia and potassium loss during maintenance digoxin therapy.维持地高辛治疗期间低钾血症和钾丢失所致的心律失常
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Reduced concentrations of potassium, magnesium, and sodium-potassium pumps in human skeletal muscle during treatment with diuretics.使用利尿剂治疗期间,人体骨骼肌中钾、镁浓度及钠钾泵浓度降低。
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[The need of potassium loss compensation in treatment with diuretics].[利尿剂治疗中钾丢失补偿的必要性]
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[The role of potassium-sparing diuretics in the treatment of cardiac insufficiency].
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引用本文的文献

1
Errors and misconceptions in drug prescribing.药物处方中的错误与误解。
J R Coll Physicians Lond. 1980 Jan;14(1):58-64.
2
Drug attributed alterations in potassium handling in congestive cardiac failure.药物引起的充血性心力衰竭患者钾代谢异常
Eur J Clin Pharmacol. 1982;23(1):21-5. doi: 10.1007/BF01061372.
3
Total body electrolyte composition in patients with heart failure: a comparison with normal subjects and patients with untreated hypertension.心力衰竭患者的全身电解质组成:与正常受试者及未经治疗的高血压患者的比较。
Br Heart J. 1987 Sep;58(3):230-8. doi: 10.1136/hrt.58.3.230.
4
Diuretics and potassium in the elderly.老年人的利尿剂与钾
J R Coll Physicians Lond. 1987 Apr;21(2):148-52.
5
Acute and long-term renal and metabolic effects of piretanide in congestive cardiac failure.吡咯他尼对充血性心力衰竭的急性和长期肾脏及代谢影响。
Br J Clin Pharmacol. 1988 Aug;26(2):143-54. doi: 10.1111/j.1365-2125.1988.tb03380.x.
6
The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure.钾补充剂、螺内酯或氨氯地平对心力衰竭患者钾状态的影响。
Postgrad Med J. 1978 Jun;54(632):405-9. doi: 10.1136/pgmj.54.632.405.

本文引用的文献

1
The exchangeable potassium content of normal women.正常女性的可交换钾含量。
J Clin Invest. 1952 Apr;31(4):367-9. doi: 10.1172/JCI102617.
2
The distribution of sodium and potassium in man.人体中钠和钾的分布。
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The measurement of exchangeable potassium in man by isotope dilution.用同位素稀释法测定人体可交换钾
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Content and distribution of potassium and chloride in adults.成人钾和氯的含量及分布
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EXCHANGEABLE SODIUM, BODY POTASSIUM, AND BODY WATER IN PREVIOUSLY EDEMATOUS CARDIAC PATIENTS: EVIDENCE FOR OSMOTIC INACTIVATION OF CATION.既往有水肿的心脏病患者体内的可交换钠、机体钾和机体水分:阳离子渗透失活的证据
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BODY COMPOSITION IN HEART DISEASE. TOTAL EXCHANGEABLE POTASSIUM, TOTAL EXCHANGEABLE SODIUM, TOTAL EXCHANGEABLE CHLORIDE AND DERIVED VALUES FOR BODY COMPOSITION IN CARDIAC DISEASE WITH AND WITHOUT EDEMA.心脏病中的身体成分。患有和未患水肿的心脏病患者的总可交换钾、总可交换钠、总可交换氯及身体成分的衍生值。
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Exchangeable potassium as a parameter of body composition.
Metabolism. 1960 May;9:456-71.
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The interrelation between total exchangeable sodium, potassium and chloride, and lean body mass in man.人体中可交换钠、钾、氯总量与去脂体重之间的相互关系。
Clin Sci. 1959 May;18:175-84.
10
Exchangeable potassium in wasting, amyotrophy, heart-disease, and cirrhosis of the liver.
Lancet. 1961 Apr 1;1(7179):681-7. doi: 10.1016/s0140-6736(61)91719-6.