Kanegusuku Hélcio, Ritti-Dias Raphael M, Barbosa Pâmela Yuki Igarasi, das Neves Guelfi Erica Tardelli, Okamoto Erika, Miranda Camila Souza, de Paula Oliveira Tatiana, Piemonte Maria Elisa Pimentel
Hospital Israelita Albert Einstein, São Paulo, Brazil.
Graduated Program in Rehabilitation Sciences, Universidade Nove de Julho, São Paulo, Brazil.
J Exerc Rehabil. 2021 Aug 23;17(4):241-246. doi: 10.12965/jer.2142290.145. eCollection 2021 Aug.
This study evaluated the impact of motor impairment (MI) on exercise capacity and quality of life in patients with Parkinson disease (PD). One hundred ninety-two patients (≥50 years old) were divided according to the Hoehn and Yahr stages in: mild (stage I), mild to moderate (stage II), moderate (stage III), and advanced MI (stage IV). Exercise capacity (6-min walk test [6MWT]) and quality of life (Parkinson's Disease Questionnaire [PDQ-39]) were obtained. In this context, 6MWT was progressively worse with increasing the severity of MI (<0.01). Patients with advanced MI achieved 39% of predicted 6MWT of healthy subject, while subjects with mild MI achieved 83% of healthy subject (<0.01). In addition, patients with advanced MI presented higher (i.e., worse) PDQ-39 scores in summary index, cognition, mobility and activities of daily live domains compared to other groups (<0.01). Patients with moderate MI also presented worse scores in PDQ-39 summary index, mobility and activities of daily live domains in comparison with mild MI patients (<0.01). Higher MI was correlated with worse exercise capacity (6MWT: =-0.46, <0.01), with worse PDQ-39 summary index and the mobility and activities of daily live domains scores (=0.38, =0.46, and =0.43, <0.01). In conclusion, MI is related to lower exercise capacity and quality of life (i.e., PDQ-39 summary index and mobility and activities of daily live domains) in patients with PD.
本研究评估了运动障碍（MI）对帕金森病（PD）患者运动能力和生活质量的影响。192名年龄≥50岁的患者根据Hoehn和Yahr分期分为：轻度（I期）、轻度至中度（II期）、中度（III期）和重度运动障碍（IV期）。测定了运动能力（6分钟步行试验[6MWT]）和生活质量（帕金森病问卷[PDQ-39]）。在此背景下，随着运动障碍严重程度的增加，6MWT逐渐变差（<0.01）。重度运动障碍患者达到健康受试者预测6MWT的39%，而轻度运动障碍患者达到健康受试者的83%（<0.01）。此外，与其他组相比，重度运动障碍患者在综合指数、认知、运动和日常生活活动领域的PDQ-39评分更高（即更差）（<0.01）。与轻度运动障碍患者相比，中度运动障碍患者在PDQ-39综合指数、运动和日常生活活动领域的评分也更差（<0.01）。更高的运动障碍程度与更差的运动能力（6MWT：=-0.46，<0.01）、更差的PDQ-39综合指数以及运动和日常生活活动领域评分（=0.38、=0.46和=0.43，<0.01）相关。总之，运动障碍与帕金森病患者较低的运动能力和生活质量（即PDQ-39综合指数以及运动和日常生活活动领域）相关。
