患有外周动脉疾病患者的功能和心血管测量：男性和女性之间的比较。
Functional and Cardiovascular Measurements in Patients With Peripheral Artery Disease: COMPARISON BETWEEN MEN AND WOMEN.
机构信息
Universidade Nove de Julho, São Paulo, Brazil (Drs Correia, de Sousa, and Ritti-Dias); Hospital Israelita Albert Einstein, São Paulo, Brazil (Drs Wolosker and Cucato); Federal University of Sergipe, Brazil (Dr Andrade-Lima); Associated Program of Physical Education, University of Pernambuco, Brazil (Mr Germano-Soares); Department of Physical Medicine and Rehabilitation, Penn State College of Medicine, Hershey, Pennsylvania (Dr Gardner); and Hospital das Clínicas, University of São Paulo, Brazil (Drs Zerati and Puech-Leao).
出版信息
J Cardiopulm Rehabil Prev. 2020 Jan;40(1):24-28. doi: 10.1097/HCR.0000000000000437.
PURPOSE
To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD).
METHODS
This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability.
RESULTS
Women had lower claudication onset distance (P = .033) and 6MWT distance (P < .001), and similar percentage of the predicted 6MWT distance (P > .05). Women had higher pulse pressure (P = .002), augmentation index (P < .001), augmentation index corrected by 75 bpm (P < .001), and brachial and central systolic blood pressure (P = .041 and P = .029). Diastolic blood pressure, pulse wave velocity, and heart rate variability were similar between sexes (P > .05).
CONCLUSION
Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD.
目的
比较男性和女性外周动脉疾病（PAD）患者的功能和心血管变量。
方法
这是一项观察性、横断面研究，共纳入 67 名女性和 144 名男性（年龄分别为 66±9 和 67±10 岁）PAD 患者。患者接受临床评估、6 分钟步行试验（6MWT）和心血管评估，包括血压、动脉僵硬度指标和心率变异性。
结果
女性跛行起始距离较低（P=0.033）和 6MWT 距离较短（P<0.001），但预测的 6MWT 距离百分比相似（P>0.05）。女性的脉压较高（P=0.002）、增强指数较高（P<0.001）、校正 75 bpm 后的增强指数较高（P<0.001），肱动脉和中心收缩压较高（P=0.041 和 P=0.029）。性别之间的舒张压、脉搏波速度和心率变异性无显著差异（P>0.05）。
结论
尽管男女之间预测的 6MWT 表现相似，但女性的血压和波反射指标高于男性。PAD 女性应强调降低血压和波反射的干预措施。
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