Institute of Pharmaceutical Science, King's College London, Stamford Street, London, SE1 9NH, UK.
Department of Analytical, Environmental & Forensic Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
Bioanalysis. 2021 Sep;13(18):1415-1425. doi: 10.4155/bio-2021-0076. Epub 2021 Sep 16.
Nicomorphine is rapidly metabolized mainly to the biologically active 6-nicotinoyl morphine and morphine. In sport, morphine and nicomorphine use is prohibited whereas codeine use is permitted. Accredited laboratories routinely test for morphine hence must be able to distinguish morphine, as a metabolite of a prohibited substance, from that whose use is permitted. Here we show a relatively simple method to synthesize the nicomorphine metabolites, 3-nicotinoyl and 6-nicotinoyl morphine, and indicate how they may be used to identify nicomorphine administration. This approach should help confirm that it is not codeine, an allowable analgesic in sport, that has been administered.
尼可吗啡主要迅速代谢为具有生物活性的 6-烟酰吗啡和吗啡。在运动中，吗啡和尼可吗啡的使用是被禁止的，而可待因的使用是被允许的。经过认证的实验室通常会检测吗啡，因此必须能够将作为禁用物质代谢物的吗啡与允许使用的吗啡区分开来。在这里，我们展示了一种相对简单的方法来合成尼可吗啡代谢物，即 3-烟酰吗啡和 6-烟酰吗啡，并指出它们如何用于鉴定尼可吗啡的使用。这种方法应该有助于确认被管理的不是可待因，一种在运动中允许使用的止痛药。
