Maes M, De Ruyter M, Suy E
Department of Psychiatry, University Hospital of Antwerpen, Edegem, Belgium.
Acta Psychiatr Belg. 1987;87:633-9.
The pre- and postdexamethasone cortisol levels are determined at 8 a.m. in 106 depressive patients. The patients are classified according to DSM-III in two categories: minor depression (300.40, 296.82, 309.00) and major depression (296.X2, 296.X3, 296.X4). The cortisol suppression index (CSI) e.g. the ratio of pre- and postdexamethasone cortisol levels is calculated. The clinical relevance of the CSI for major depression is compared to the dexamethasone suppression test (DST). The CSI is significantly (p = 0.018) lowered in patients with major depression as compared to those with minor depression. The CSI depends (r = -0.929) on changes of the postdexamethasone cortisol levels. The DST is more useful as an external validating criterion for major depression than is the CSI. The determination of the CSI is not an asset in the diagnosis of major depression.
在上午8点测定106例抑郁症患者服用地塞米松前后的皮质醇水平。根据《精神疾病诊断与统计手册》第三版（DSM-III）将患者分为两类：轻度抑郁症（300.40、296.82、309.00）和重度抑郁症（296.X2、296.X3、296.X4）。计算皮质醇抑制指数（CSI），即服用地塞米松前后皮质醇水平的比值。将重度抑郁症患者的CSI临床相关性与地塞米松抑制试验（DST）进行比较。与轻度抑郁症患者相比，重度抑郁症患者的CSI显著降低（p = 0.018）。CSI取决于服用地塞米松后皮质醇水平的变化（r = -0.929）。作为重度抑郁症的外部验证标准，DST比CSI更有用。CSI的测定对重度抑郁症的诊断并无帮助。
