Zung W W, Denton W H, Mahorney S
J Clin Psychiatry. 1984 Oct;45(10):437-8.
The cortisol suppression index (CSI) is the ratio of pre- to postdexamethasone plasma cortisol concentrations. The 8 a.m. CSI was previously found to identify 66% of a sample of psychiatric inpatients with major depression. In the present study, a 4 p.m. CSI identified 71% of psychiatric inpatients with major depression, in contrast to 53% when using DST criteria alone. This finding adds further validation to the CSI. Further studies of the utility of the CSI are suggested to help improve the detection of major depression.
皮质醇抑制指数（CSI）是地塞米松给药前后血浆皮质醇浓度的比值。先前发现上午8点的CSI可识别出66%的重度抑郁症精神科住院患者样本。在本研究中，下午4点的CSI可识别出71%的重度抑郁症精神科住院患者，而仅使用地塞米松抑制试验（DST）标准时这一比例为53%。这一发现进一步验证了CSI。建议对CSI的效用进行进一步研究，以帮助改善重度抑郁症的检测。
