Integrative Physiology Research Center, Research Group in Neuromuscular Physiology, Department of Biological Sciences, Universidade Estadual do Sudoeste da Bahia (UESB), Jequie, Bahia, Brazil.
Integrative Physiology Research Center, Research Group in Neuromuscular Physiology, Department of Biological Sciences, Universidade Estadual do Sudoeste da Bahia (UESB), Jequie, Bahia, Brazil
Clin Med Res. 2021 Sep;19(3):138-140. doi: 10.3121/cmr.2021.1569.
Maintaining adequate body water balance is one aim of hemodialysis that is obtained by changing the blood volume. However, it is known that volume withdrawal is followed by water redistribution between extra- and intra-cellular spaces. In this context, the skeletal muscle tissue represents almost 50% of the total body mass, and like other soft tissues, consists of about 70%-80% water. Body weight is the main parameter used to monitor the body water change after a hemodialysis session, but it does not allow inferring about the water redistribution between extra and intracellular spaces. Thus, the present study aimed to assess the immediate impact of hemodialysis on body weight and the thickness of the rectus femoris muscle. Fifteen male patients with end-stage renal disease took part in the study. Muscle thickness, measured with ultrasound imaging, and body weight and were measured before (Pre) and after (Post) (within 5 to 10 minutes after) an hemodialysis session. Paired t-test was used to compare Pre and Post measures, and Bayesian analysis was applied to check the probability to replicate the same results (ie, the magnitude of the evidence). Our results indicated that body weight, but not rectus femoris muscle thickness, is significantly reduced immediately after hemodialysis. The rectus femoris muscle thickness seems not to be a reliable parameter to infer water redistribution after hemodialysis session.
维持充足的体内水平衡是血液透析的一个目标，这可以通过改变血液量来实现。然而，众所周知，在血容量减少后，水会在细胞内外重新分布。在这种情况下，骨骼肌组织几乎占人体总质量的 50%，与其他软组织一样，由大约 70%-80%的水组成。体重是监测血液透析后体内水分变化的主要参数，但它不能推断细胞内外水的重新分布情况。因此，本研究旨在评估血液透析对体重和股直肌厚度的即时影响。15 名终末期肾病男性患者参与了这项研究。使用超声成像测量肌肉厚度，并在血液透析前后（透析后 5 至 10 分钟内）测量体重和。采用配对 t 检验比较前后测量值，并应用贝叶斯分析检查复制相同结果的概率（即证据的大小）。我们的结果表明，体重在血液透析后立即显著下降，但股直肌厚度没有明显变化。股直肌厚度似乎不是推断血液透析后水重新分布的可靠参数。
