一种改进的周和法斯曼蛋白质结构算法。

A modified Chou and Fasman protein structure algorithm.

作者信息

Ralph W W, Webster T, Smith T F

机构信息

MBCRR, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02115.

出版信息

Comput Appl Biosci. 1987 Sep;3(3):211-6. doi: 10.1093/bioinformatics/3.3.211.

DOI:10.1093/bioinformatics/3.3.211

PMID:3453230

Abstract

A FORTRAN program PRSTRC has been developed for protein secondary structure prediction, which is a modified Chou and Fasman (1978) analysis. This implementation carries out a running average of amino acid structure occurrence frequencies, utilizes a simple set of nucleation conditions, and allows user control over nucleation threshold and cutoff parameters. The algorithm includes prediction of the newly defined secondary structure elements: omega loops (1986). It also generates a charge distribution and hydropathy profile. Output includes a simple graphic display for a printer, or a CRT using color addition. Correct structures are predicted for T. dyscritum hemerythrin and the variable domain of mouse immunoglobin k-chain.

摘要

已经开发了一个用于蛋白质二级结构预测的FORTRAN程序PRSTRC，它是对Chou和Fasman（1978年）分析方法的改进。该程序实现了氨基酸结构出现频率的滑动平均，使用了一组简单的成核条件，并允许用户控制成核阈值和截止参数。该算法包括对新定义的二级结构元件：ω环（1986年）的预测。它还生成电荷分布和亲水性图谱。输出包括用于打印机的简单图形显示，或使用加法混色的阴极射线管显示。该程序正确预测了盘基网柄菌血蓝蛋白和小鼠免疫球蛋白κ链可变区的结构。