猴病毒40大T抗原、腺病毒E1A蛋白和Myc癌蛋白中相似转化区域的预测
Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins.
作者信息
Figge J, Webster T, Smith T F, Paucha E
机构信息
Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, Boston, Massachusetts.
出版信息
J Virol. 1988 May;62(5):1814-8. doi: 10.1128/JVI.62.5.1814-1818.1988.
Abstract
Regions containing similar elements of primary and predicted secondary structure were identified in simian virus 40 large T, adenovirus E1A, c-myc and v-myc proteins by a computer program with a set of highly specific, complex pattern descriptors. In all cases these regions were localized in domains of the respective proteins known to be required for transforming activity. We suggest that these apparently structurally similar regions may mediate a common biological function.
摘要
利用一个带有一组高度特异性、复杂模式描述符的计算机程序，在猿猴病毒40大T蛋白、腺病毒E1A蛋白、c-myc蛋白和v-myc蛋白中鉴定出了包含初级结构和预测二级结构相似元件的区域。在所有情况下，这些区域都位于各自蛋白质中已知对转化活性必需的结构域内。我们认为，这些明显结构相似的区域可能介导一种共同的生物学功能。
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