中间丝角蛋白对体外多组分互穿细胞骨架网络结构和动力学的影响。
Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of In Vitro Multicomponent Interpenetrating Cytoskeletal Networks.
机构信息
Department of Physics & John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
School of Systems Science, Beijing Normal University, Beijing 100875, China.
出版信息
Phys Rev Lett. 2021 Sep 3;127(10):108101. doi: 10.1103/PhysRevLett.127.108101.
Abstract
We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with little contribution from either microtubules or vimentin. However, vimentin dramatically impacts the relaxation, with even small amounts significantly increasing the relaxation time of the interpenetrating network. This highly unusual decoupling between dissipation and elasticity may reflect weak attractive interactions between vimentin and actin networks.
摘要
我们研究了由主要细胞骨架成分
丝状肌动蛋白、微管和中间丝角蛋白构成的互穿网络的流变性质。弹性模量主要由肌动蛋白决定，微管和角蛋白的贡献很小。然而，角蛋白对松弛有显著影响，即使少量角蛋白也会显著增加互穿网络的松弛时间。这种耗散和弹性之间的高度非耦合可能反映了角蛋白和肌动蛋白网络之间的弱吸引力相互作用。
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