Universidad Autónoma de Nuevo León, Centro de Investigación en Nutrición y Salud Pública (CINSP), Monterrey, Nuevo León, México.
Eur Rev Med Pharmacol Sci. 2021 Sep;25(17):5463-5473. doi: 10.26355/eurrev_202109_26655.
Brain-derived neurotrophic factor (BDNF) is a cornerstone in the hypothalamic regulation of food intake and energy homeostasis. Polymorphisms in the BDNF gene may thus contribute to obesity traits. The aim of this investigation was to analyze the association of rs6265 and rs7934165 BDNF polymorphisms in women from Northeast Mexico classified as obese or overweight using their BMI and waist-to-height ratio (WHtR).
A total of 296 women were enrolled and further divided into normal weight and obese overweight groups according to their BMI status and WHtR classifications, which were low and high at < 0.50 and ≥ 0.50, respectively. Genotyping of BDNF rs6265 and rs7934165 polymorphisms was performed using a TaqMan assay. Distinct anthropometric, biochemical, clinical, and dietary parameters were obtained and used as covariates in the statistical analyses.
The rs6265-G allele and its homozygote state (GG) were the most prominent without statistically significant differences between groups (p = 0.412). The study of rs7934165 with BMI showed marginal associations. Moreover, the rs7934165-AA genotype was more frequent among individuals with a high WHtR than those with a low WHtR (43.4 vs. 25.2%, p = 0.01). This association was maintained after adjustments for age and caloric intake through logistic regression analysis (OR = 2.20, 95% CI = 1.15-4.18, p = 0.016).
The present study indicates that the BDNF-rs7934165-AA genotype is associated with a higher WHtR which is related to central obesity and its comorbidities. This suggests that this SNP could act as a potential biomarker for central obesity and cardiometabolic risk.
脑源性神经营养因子（BDNF）是下丘脑调节摄食和能量平衡的基石。BDNF 基因的多态性可能与肥胖特征有关。本研究旨在分析墨西哥东北部女性中 BDNF rs6265 和 rs7934165 多态性与肥胖或超重的关系，这些女性根据 BMI 和腰高比（WHtR）进行分类。
共纳入 296 名女性，根据 BMI 状况和 WHtR 分类进一步分为正常体重和超重肥胖组，分别为<0.50 和≥0.50。使用 TaqMan 测定法对 BDNF rs6265 和 rs7934165 多态性进行基因分型。获得不同的人体测量学、生化、临床和饮食参数，并将其作为统计分析的协变量。
rs6265-G 等位基因及其纯合状态（GG）最为突出，两组间无统计学差异（p=0.412）。rs7934165 与 BMI 的研究显示出边缘关联。此外，高 WHtR 个体的 rs7934165-AA 基因型比低 WHtR 个体更常见（43.4%比 25.2%，p=0.01）。这种关联在通过逻辑回归分析调整年龄和热量摄入后仍然存在（OR=2.20，95%CI=1.15-4.18，p=0.016）。
本研究表明，BDNF-rs7934165-AA 基因型与较高的 WHtR 相关，WHtR 与中心性肥胖及其合并症有关。这表明该 SNP 可能作为中心性肥胖和心血管代谢风险的潜在生物标志物。
