Ma Xian-Yong, Qiu Wei Qiao, Smith Caren E, Parnell Laurence D, Jiang Zong-Yong, Ordovas Jose M, Tucker Katherine L, Lai Chao-Qiang
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
J Obes. 2012;2012:102942. doi: 10.1155/2012/102942. Epub 2012 Dec 27.
Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n = 242) with the GG genotype had higher BMI (P = 0.009), waist circumference (P = 0.002), hip (P = 0.002), and weight (P = 0.03) than GA or AA carriers (n = 94). They had twice the risk of being overweight (BMI ≥ 25) relative to GA or AA carriers (OR = 2.08, CI = 1.02-4.23, and P = 0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n = 595) with the GG genotype had significantly lower BMI (P = 0.009), hip (P = 0.029), and weight (P = 0.027) than GA or AA carriers (n = 216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27-0.91, and P = 0.024). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.
脑源性神经营养因子（BDNF）与体重和食欲的调节有关。本研究的目的是在波士顿波多黎各健康研究中，检测BDNF基因中的一个功能变体（rs6265）与饮食摄入对肥胖性状的相互作用。对1147名波多黎各成年人的BDNF rs6265进行基因分型，并检测其与肥胖相关性状的关联。与GA或AA携带者（n = 94）相比，GG基因型的男性（n = 242）具有更高的体重指数（P = 0.009）、腰围（P = 0.002）、臀围（P = 0.002）和体重（P = 0.03）。相对于GA或AA携带者，他们超重（体重指数≥25）的风险是其两倍（比值比=2.08，可信区间=1.02 - 4.23，P = 0.043）。rs6265与多不饱和脂肪酸（PUFA）摄入之间的相互作用与男性的体重指数、臀围和体重有关，而n-3∶n-6 PUFA比值与男性的腰围有关。相比之下，与GA或AA携带者（n = 216）相比，GG基因型的女性（n = 595）的体重指数（P = 0.009）、臀围（P = 0.029）和体重（P = 0.027）显著更低。与GA或AA携带者相比，GG基因型的女性超重的可能性降低了50%（比值比=0.50，可信区间=0.27 - 0.91，P = 0.024）。总之，BDNF rs6265与肥胖风险的性别差异相关，并与影响波士顿波多黎各男性肥胖性状的PUFA摄入相互作用。
