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2008 年至 2018 年美国心力衰竭住院治疗趋势。

Trends in Heart Failure Hospitalizations in the US from 2008 to 2018.

机构信息

Division of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Yale University School of Medicine, New Haven, CT.

出版信息

J Card Fail. 2022 Feb;28(2):171-180. doi: 10.1016/j.cardfail.2021.08.020. Epub 2021 Sep 15.

Abstract

BACKGROUND

Heart failure (HF) is a major driver of health care costs in the United States and is increasing in prevalence. There is a paucity of contemporary data examining trends among hospitalizations for HF that specifically compare HF with reduced or preserved ejection fraction (HFrEF or HFpEF, respectively).

METHODS AND RESULTS

Using the National Inpatient Sample, we identified 11,692,995 hospitalizations due to HF. Hospitalizations increased from 1,060,540 in 2008 to 1,270,360 in 2018. Over time, the median age of patients hospitalized because of HF decreased from 76.0 to 73.0 years (P < 0.001). There were increases in the proportions of Black patients (18.4% in 2008 to 21.2% in 2018) and of Hispanic patients (7.1% in 2008 to 9.0% in 2018; P < 0.001, all). Over the study period, we saw an increase in comorbid diabetes, sleep apnea and obesity (P < 0.001, all) in the entire cohort with HF as well as in the HFrEF and HFpEF subgroups. Persons admitted because of HFpEF were more likely to be white and older compared to admissions because of HFrEF and also had lower costs. Inpatient mortality decreased from 2008 to 2018 for overall HF (3.3% to 2.6%) and HFpEF (2.4% to 2.1%; P < 0.001, all) but was stable for HFrEF (2.8%, both years). Hospital costs, adjusted for inflation, decreased in all 3 groups across the study period, whereas length of stay was relatively stable over time for all groups.

CONCLUSIONS

The volume of patients hospitalized due to HF has increased over time and across subgroups of ejection fraction. The demographics of HF, HFrEF and HFpEF have become more diverse over time, and hospital inpatient costs have decreased, regardless of HF type. Inpatient mortality rates improved for overall HF and HFpEF admissions but remained stable for HFrEF admissions.

摘要

背景

心力衰竭(HF)是美国医疗保健成本的主要驱动因素,其患病率正在上升。目前,关于专门比较射血分数降低(HFrEF)或射血分数保留(HFpEF)的心力衰竭住院治疗趋势的当代数据很少。

方法和结果

我们使用国家住院患者样本,确定了 11692995 例因 HF 住院的病例。2008 年至 2018 年,因 HF 住院的病例从 1060540 例增加到 1270360 例。随着时间的推移,因 HF 住院的患者的中位年龄从 76.0 岁降至 73.0 岁(P < 0.001)。黑人患者(2008 年为 18.4%,2018 年为 21.2%)和西班牙裔患者(2008 年为 7.1%,2018 年为 9.0%)的比例均有所增加(P < 0.001,均)。在研究期间,我们观察到整个 HF 队列以及 HFrEF 和 HFpEF 亚组的合并糖尿病、睡眠呼吸暂停和肥胖的比例均有所增加(P < 0.001,均)。因 HFpEF 住院的患者比因 HFrEF 住院的患者更有可能是白人且年龄更大,并且住院费用也更低。2008 年至 2018 年,因整体 HF(从 3.3%降至 2.6%)和 HFpEF(从 2.4%降至 2.1%;P < 0.001,均)的住院死亡率下降,但 HFrEF 的住院死亡率稳定(均为 2.8%)。在整个研究期间,所有 3 组的住院费用(经通胀调整后)均有所下降,而所有组的住院时间在一段时间内相对稳定。

结论

因 HF 住院的患者数量随着时间的推移和射血分数亚组的变化而增加。HF、HFrEF 和 HFpEF 的人口统计学特征随着时间的推移变得更加多样化,无论 HF 类型如何,住院医疗费用都有所下降。HFpEF 和整体 HF 入院患者的住院死亡率有所改善,但 HFrEF 入院患者的死亡率保持稳定。

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