School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
Adv Colloid Interface Sci. 2021 Oct;296:102521. doi: 10.1016/j.cis.2021.102521. Epub 2021 Sep 14.
Bioadhesives have reached significant milestones over the past two decades. Research has shown not only to produce adhesives capable of adhering to dry tissue but recently wet tissue as well. However, most bioadhesives developed have exhibited high adhesion strength yet lack other properties required for versatility in application, such as elasticity, biocompatibility and biodegradability. Adapting from limitations met from early bioadhesives and meeting the current demand allows novel bioadhesives to reach new milestones for the future. In this review, we overview the progression and variations of bioadhesives, current trends, characterisation techniques and conclude with future perspectives for bioadhesives for tissue engineering applications.
生物粘合剂在过去二十年中取得了重大进展。研究表明，不仅可以生产出能够黏附在干燥组织上的粘合剂，而且最近还可以黏附在湿润组织上。然而，大多数开发的生物粘合剂都表现出了很高的黏附强度，但缺乏在应用中具有多功能性所需的其他特性，如弹性、生物相容性和可生物降解性。从早期生物粘合剂遇到的局限性中进行调整，并满足当前的需求，使得新型生物粘合剂能够为未来开辟新的里程碑。在这篇综述中，我们概述了生物粘合剂的进展和变化、当前的趋势、特性化技术，并对生物粘合剂在组织工程应用中的未来前景进行了总结。
