接种两剂不同接种间隔的马疱疹病毒1型活疫苗的马匹中病毒中和抗体的持久性。
Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals.
作者信息
Bannai Hiroshi, Kambayashi Yoshinori, Tsujimura Koji, Nagashima Tsuyoshi, Takebe Naoya, Tominari Masataka, Nemoto Manabu, Ohta Minoru
机构信息
Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Hidaka Training and Research Center, Japan Racing Association, Hokkaido 057-0171, Japan.
出版信息
J Equine Sci. 2021;32(3):99-102. doi: 10.1294/jes.32.99. Epub 2021 Sep 6.
The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maintained significantly higher than those before the first vaccination (P<0.05) were up to 5 months in horses that received the vaccination with a 1-month interval (n=17) and 7 months for those that received it with a 2-month (n=17) or 3-month interval (n=14 or 17). The vaccination program with the 2-month interval was the most effective in maintaining VN antibodies for a long duration with the smallest gap of antibody decline between the first and second vaccinations.
对接种了2剂活的1型马疱疹病毒疫苗且接种间隔不同（1至3个月）的马匹的抗体反应，就病毒中和（VN）抗体的持久性进行了评估。对于接种间隔为1个月的马匹（n = 17），几何平均VN滴度维持显著高于首次接种前水平（P<0.05）的持续时间长达5个月；对于接种间隔为2个月（n = 17）或3个月（n = 14或17）的马匹，该持续时间为7个月。接种间隔为2个月的疫苗接种方案在长时间维持VN抗体方面最为有效，且首次和第二次接种之间抗体下降的差距最小。
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