年龄和妊娠对马针对马疱疹病毒1的抗体及细胞介导免疫反应的影响。
Effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1.
作者信息
Gerber J D, Marron A E, Bass E P, Beckenhauer W H
出版信息
Can J Comp Med. 1977 Oct;41(4):471-8.
The cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. Six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. However, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured by the lymphocyte transformation test. Eighteen to 21 month old horses showed four to 64-fold increases in anti-equine herpesvirus 1 serum neutralizing antibody titer following vaccination, but the cell-mediated immune response to equine herpesvirus 1 was low or absent. Only after revaccination did they show an increased cell-mediated immune response to equine herpesvirus 1. The cell-mediated immune response of mares in the latter stages of pregnancy to equine herpesivurs 1 was suppressed although antibody titers increased as much as 16-fold following exposure to virulent equine herpesvirus 1.
对不同年龄的马匹以及怀孕母马针对马疱疹病毒1型抗原的细胞介导免疫反应和抗体反应进行了检测。6至8月龄的马匹在用改良活马疱疹病毒1型疫苗接种和再次接种后，抗马疱疹病毒1型血清中和抗体要么没有增加，要么仅有轻微增加。然而，通过淋巴细胞转化试验测定，这些相同的马匹对马疱疹病毒1型的细胞介导免疫反应显著增加。18至21月龄的马匹在接种后抗马疱疹病毒1型血清中和抗体效价增加了4至64倍，但对马疱疹病毒1型的细胞介导免疫反应较低或不存在。只有在再次接种后，它们才表现出对马疱疹病毒1型的细胞介导免疫反应增加。怀孕后期母马对马疱疹病毒1型的细胞介导免疫反应受到抑制，尽管在接触强毒马疱疹病毒1型后抗体效价增加了多达16倍。
Zotero 插件