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与（Thunb.）莫尔登克相关的草药性肝损伤：危险因素、分子及机制细节

Herb-Induced Liver Injury Related to (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics.

作者信息

Zhai Xing-Ran, Zou Zheng-Sheng, Wang Jia-Bo, Xiao Xiao-He

机构信息

Peking University 302 Clinical Medical School, Beijing, China.

Medical School of Chinese PLA, Beijing, China.

出版信息

Front Pharmacol. 2021 Sep 2;12:738577. doi: 10.3389/fphar.2021.738577. eCollection 2021.

DOI:10.3389/fphar.2021.738577
PMID:34539416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8443768/
Abstract

Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most severe side effects of herbal medicine which is an increasing concern around the world. (Thunb.) Moldenke ( Thunb., PM) is the most common herb that can cause herb-induced liver injury (HILI). The recent scientific and technological advancements in clinical and basic research are paving the way for a better understanding of the molecular aspects of PM-related HILI (PM-HILI). This review provides an updated overview of the clinical characteristics, predisposing factors, hepatotoxic components, and molecular mechanisms of PM-HILI. It can also aid in a better understanding of HILI and help in further research on the same.

摘要

草药在亚洲和西方都被广泛使用。肝毒性是草药最严重的副作用之一，这在全球范围内日益受到关注。绵马贯众（绵马，紫萁科）是最常见的可导致药物性肝损伤（HILI）的草药。临床和基础研究方面的最新科技进展为更好地理解与绵马贯众相关的药物性肝损伤（PM-HILI）的分子机制铺平了道路。本综述提供了PM-HILI的临床特征、易感因素、肝毒性成分和分子机制的最新概述。它还有助于更好地理解药物性肝损伤，并有助于对此进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/5c0a41f0d3a6/fphar-12-738577-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/23769e88aa1d/fphar-12-738577-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/35471cfef9d3/fphar-12-738577-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/1d29f5756a63/fphar-12-738577-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/9ac1f8d08207/fphar-12-738577-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/5c0a41f0d3a6/fphar-12-738577-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/23769e88aa1d/fphar-12-738577-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/35471cfef9d3/fphar-12-738577-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/1d29f5756a63/fphar-12-738577-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/9ac1f8d08207/fphar-12-738577-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d8/8443768/5c0a41f0d3a6/fphar-12-738577-g005.jpg

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本文引用的文献

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