• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[具体物质]不同加工产品对肝脏的影响。 需注意，原文中“of ”中间缺少具体内容。

Effects of Different Processed Products of on the Liver.

作者信息

Li Ruo-Lan, Gao Feng, Yan Shu-Ting, Ou Li, Li Ming, Chen Lin, Wei Pei-Feng, Gao Zong-Qiang

机构信息

College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Road, Qindu District, Xianyang, Shaanxi 712046, China.

出版信息

Evid Based Complement Alternat Med. 2020 Mar 9;2020:5235271. doi: 10.1155/2020/5235271. eCollection 2020.

DOI:10.1155/2020/5235271
PMID:32215041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7085390/
Abstract

OBJECTIVE

Based on in vitro and in vivo experimental studies, the changes of the main components of and different processed products and their effects on hepatotoxicity were investigated.

METHODS

The components of different processed products of and different processed products and their effects on hepatotoxicity were investigated.

RESULTS

With the extension of processing time, the contents of various chemical components in and different processed products and their effects on hepatotoxicity were investigated. and different processed products and their effects on hepatotoxicity were investigated. and different processed products and their effects on hepatotoxicity were investigated. and different processed products and their effects on hepatotoxicity were investigated.

CONCLUSION

The content of the main components in Radix can be affected by processing time; stilbene glycoside may be the main component leading to liver injury. The degree of liver injury caused by Radix is negatively correlated with processing time. and different processed products and their effects on hepatotoxicity were investigated. and different processed products and their effects on hepatotoxicity were investigated.

摘要

目的

基于体外和体内实验研究，考察[具体药物名称]及其不同炮制品主要成分的变化及其对肝毒性的影响。

方法

考察[具体药物名称]不同炮制品的成分及其对肝毒性的影响。

结果

随着炮制时间的延长，考察了[具体药物名称]及其不同炮制品中各种化学成分的含量及其对肝毒性的影响。考察了[具体药物名称]及其不同炮制品及其对肝毒性的影响。考察了[具体药物名称]及其不同炮制品及其对肝毒性的影响。考察了[具体药物名称]及其不同炮制品及其对肝毒性的影响。

结论

[具体药物名称]主要成分的含量可受炮制时间影响；二苯乙烯苷可能是导致肝损伤的主要成分。[具体药物名称]所致肝损伤程度与炮制时间呈负相关。考察了[具体药物名称]及其不同炮制品及其对肝毒性的影响。考察了[具体药物名称]及其不同炮制品及其对肝毒性的影响。

需注意，原文中多次重复相同内容，且有部分关键信息缺失（如具体药物名称），翻译出来的内容可能存在信息不完整的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/8613cfb31e53/ECAM2020-5235271.013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/66e795672ad9/ECAM2020-5235271.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/7ac5eb9ef339/ECAM2020-5235271.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/e120d978036f/ECAM2020-5235271.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/4d41fc142964/ECAM2020-5235271.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/70d37530e6e0/ECAM2020-5235271.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/bf129c2a98f4/ECAM2020-5235271.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/f1c008dece35/ECAM2020-5235271.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/a9e63f6bbddd/ECAM2020-5235271.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/c5af9e1c1d2b/ECAM2020-5235271.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/3ea0cd215ca3/ECAM2020-5235271.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/d6c89dd62e45/ECAM2020-5235271.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/dd89db33a574/ECAM2020-5235271.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/8613cfb31e53/ECAM2020-5235271.013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/66e795672ad9/ECAM2020-5235271.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/7ac5eb9ef339/ECAM2020-5235271.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/e120d978036f/ECAM2020-5235271.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/4d41fc142964/ECAM2020-5235271.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/70d37530e6e0/ECAM2020-5235271.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/bf129c2a98f4/ECAM2020-5235271.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/f1c008dece35/ECAM2020-5235271.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/a9e63f6bbddd/ECAM2020-5235271.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/c5af9e1c1d2b/ECAM2020-5235271.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/3ea0cd215ca3/ECAM2020-5235271.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/d6c89dd62e45/ECAM2020-5235271.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/dd89db33a574/ECAM2020-5235271.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/7085390/8613cfb31e53/ECAM2020-5235271.013.jpg

相似文献

1
Effects of Different Processed Products of on the Liver.[具体物质]不同加工产品对肝脏的影响。 需注意，原文中“of ”中间缺少具体内容。
Evid Based Complement Alternat Med. 2020 Mar 9;2020:5235271. doi: 10.1155/2020/5235271. eCollection 2020.
2
Polygonum multiflorum Thunb. Induces hepatotoxicity in SD rats and hepatocyte spheroids by Disrupting the metabolism of bilirubin and bile acid.何首乌通过破坏胆红素和胆汁酸的代谢在 SD 大鼠和肝细胞球中诱导肝毒性。
J Ethnopharmacol. 2022 Oct 5;296:115461. doi: 10.1016/j.jep.2022.115461. Epub 2022 Jun 18.
3
Research progress on hepatotoxicity mechanism of polygonum multiflorum and its main components.何首乌及其主要成分肝毒性机制的研究进展。
Toxicon. 2024 Sep;248:108040. doi: 10.1016/j.toxicon.2024.108040. Epub 2024 Jul 20.
4
Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity.《拇指：化学分析、加工机制、质量评估及肝毒性综述》
Front Pharmacol. 2018 Apr 16;9:364. doi: 10.3389/fphar.2018.00364. eCollection 2018.
5
[Study on potential hepatotoxicity of main monomers of Polygonum multiflorum based on liver micro-tissue].基于肝脏微组织的何首乌主要单体潜在肝毒性研究
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2954-2959. doi: 10.19540/j.cnki.cjcmm.20200322.401.
6
In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism.何首乌活性成分对脂质代谢相关酶的体外作用。
J Ethnopharmacol. 2014 May 14;153(3):763-70. doi: 10.1016/j.jep.2014.03.042. Epub 2014 Mar 27.
7
Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis.生熟何首乌诱导大鼠肝损伤的尿液代谢组学研究及模式识别与通路分析
J Ethnopharmacol. 2016 Dec 24;194:299-306. doi: 10.1016/j.jep.2016.09.011. Epub 2016 Sep 9.
8
[Developing spectrum-toxicity relationship with rough set theory for hepatotoxicity material basis of Polygonum multiflorum].基于粗糙集理论建立何首乌肝毒性物质基础的谱-毒关系研究
Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):509-517. doi: 10.19540/j.cnki.cjcmm.20181114.001.
9
[Effects of extract of Polygonum multiflorum on cell cycle arrest and apoptosis of human liver cell line L02].何首乌提取物对人肝细胞系L02细胞周期阻滞及凋亡的影响
Zhong Xi Yi Jie He Xue Bao. 2010 Jun;8(6):554-61. doi: 10.3736/jcim20100608.
10
Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism.生首乌与制首乌差异性肝毒性及其机制研究。
BMC Complement Med Ther. 2024 Apr 17;24(1):161. doi: 10.1186/s12906-024-04463-9.

引用本文的文献

1
Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism.生首乌与制首乌差异性肝毒性及其机制研究。
BMC Complement Med Ther. 2024 Apr 17;24(1):161. doi: 10.1186/s12906-024-04463-9.
2
, the Hmong Medicinal Flora: A Comprehensive Review of Its Phytochemical, Pharmacological and Pharmacokinetic Characteristics.《苗药本草：其植物化学、药理学和药代动力学特征的全面综述》。
Molecules. 2022 Sep 28;27(19):6407. doi: 10.3390/molecules27196407.
3
Herb-Induced Liver Injury Related to (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics.

本文引用的文献

1
Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats.麒麟丸通过抑制模型大鼠睾丸中Bax-caspase-9凋亡途径来缓解少弱精子症。
Oncotarget. 2018 Apr 24;9(31):21770-21782. doi: 10.18632/oncotarget.24985.
2
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways.用于预测经多种酶途径代谢的药物在孕妇体内药代动力学的基于生理的药代动力学模型。
Clin Pharmacokinet. 2018 Jun;57(6):749-768. doi: 10.1007/s40262-017-0594-5.
3
A nationwide study of the incidence rate of herb-induced liver injury in Korea.
与（Thunb.）莫尔登克相关的草药性肝损伤：危险因素、分子及机制细节
Front Pharmacol. 2021 Sep 2;12:738577. doi: 10.3389/fphar.2021.738577. eCollection 2021.
一项韩国全国范围内的草药诱导肝损伤发病率研究。
Arch Toxicol. 2017 Dec;91(12):4009-4015. doi: 10.1007/s00204-017-2007-9. Epub 2017 Jun 20.
4
Caspases and their substrates.半胱天冬酶及其底物。
Cell Death Differ. 2017 Aug;24(8):1380-1389. doi: 10.1038/cdd.2017.44. Epub 2017 May 12.
5
Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum.筛查与滋补草药何首乌特异肝毒性相关的主要成分。
Front Med. 2017 Jun;11(2):253-265. doi: 10.1007/s11684-017-0508-9. Epub 2017 Mar 17.
6
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival.半胱天冬酶-3和半胱天冬酶-8在乳腺癌中的表达：半胱天冬酶-3与生存率相关。
Apoptosis. 2017 Mar;22(3):357-368. doi: 10.1007/s10495-016-1323-5.
7
Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK.丙泊酚通过调节Bcl-2、Bax、Caspase3、Kir6.1和p-JNK的表达抑制缺氧/复氧诱导的人脐静脉平滑肌细胞凋亡。
Oxid Med Cell Longev. 2016;2016:1518738. doi: 10.1155/2016/1518738. Epub 2016 Jan 5.
8
Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.用于生物催化的细胞色素P450酶的定向进化：利用具有宽松底物特异性的酶的催化多功能性。
Biochem J. 2015 Apr 1;467(1):1-15. doi: 10.1042/BJ20141493.
9
Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series.何首乌相关肝损伤：病例报告和病例系列的系统评价
Evid Based Complement Alternat Med. 2015;2015:459749. doi: 10.1155/2015/459749. Epub 2015 Jan 12.
10
Combination analysis in genetic polymorphisms of drug-metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese population.日本人群中药物代谢酶CYP1A2、CYP2C9、CYP2C19、CYP2D6和CYP3A5基因多态性的联合分析
Int J Med Sci. 2015 Jan 1;12(1):78-82. doi: 10.7150/ijms.10263. eCollection 2015.