FTO rs9939609 多态性与青少年肥胖风险：基于证据的荟萃分析。
The FTO rs9939609 polymorphism and obesity risk in teens: Evidence-based meta-analysis.
机构信息
Escola de Ciências Médicas, Biomédicas e Farmacêuticas, Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil.
Programa de Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil.
出版信息
Obes Res Clin Pract. 2018 Sep-Oct;12(5):432-437. doi: 10.1016/j.orcp.2018.08.001. Epub 2018 Aug 10.
OBJECTIVE
This meta-analysis aims evaluate the association of the polymorphism rs9939609 of FTO with the risk of obesity among children and adolescents, based on the assessment of four genetic models: codominant, dominant, recessive alleles model.
METHODS
Case-control studies, published between the years 2011-2015, were selected from tree available databases (PubMed, Scopus and Web of Science) and were analysed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Thirteen studies were included totalling 15,613 participants, divided into 7311 cases and 8302 controls.
RESULTS
The FTO rs9939609 polymorphism was significantly associated with increased risk of obesity in children and adolescents for homozygous genotypes AA and heterozygous AT (TT vs. AT+AA: OR=0.723, 95% CI 0.629 to 0.832; p<0.0001).
CONCLUSION
This meta-analysis shows that the FTO rs9939609 polymorphism in the gene is a risk factor for obesity in children and adolescents with the presence of the A allele, both homozygous genotype AA situation, as heterozygous AT.
目的
本荟萃分析旨在评估 FTO 基因 rs9939609 多态性与儿童和青少年肥胖风险之间的关联，评估采用四种遗传模型：共显性、显性、隐性等位基因模型。
方法
从三个可用数据库（PubMed、Scopus 和 Web of Science）中筛选出 2011 年至 2015 年间发表的病例对照研究，并按照系统评价和荟萃分析的首选报告项目（PRISMA）建议进行分析。共纳入了 13 项研究，总计 15613 名参与者，分为 7311 例病例和 8302 例对照。
结果
FTO rs9939609 多态性与儿童和青少年肥胖的风险显著相关，对于纯合基因型 AA 和杂合基因型 AT（TT 与 AT+AA：OR=0.723，95%CI 0.629 至 0.832；p<0.0001）。
结论
本荟萃分析表明，FTO 基因 rs9939609 多态性是儿童和青少年肥胖的危险因素，携带 A 等位基因，无论是纯合基因型 AA 还是杂合基因型 AT 都存在这种情况。
Zotero 插件