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驱动蛋白家族成员20B（KIF20B）促进细胞增殖，可能是胰腺癌的潜在治疗靶点。

KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer.

作者信息

Chen Jing, Zhao Cui-Cui, Chen Fei-Ran, Feng Guo-Wei, Luo Fei, Jiang Tao

机构信息

Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.

Department of VIP Ward, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.

出版信息

J Oncol. 2021 Sep 9;2021:5572402. doi: 10.1155/2021/5572402. eCollection 2021.

DOI:10.1155/2021/5572402
PMID:34539784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8445734/
Abstract

KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.

摘要

据报道，驱动蛋白家族（KIFs）在多种肿瘤中起关键作用，而KIF20B是KIFs中的一种蛋白质。在本研究中，KIF20B在GEO数据库和我院数据中高表达，KIF20B的高表达提示预后不良。我们采用免疫组化法检测胰腺癌组织及癌旁正常组织中KIF20B的表达。在胰腺癌细胞系PANC-1和BxPC-3细胞中敲低KIF20B，通过集落形成实验、CCK8以及Ki-67和PCNA的蛋白质免疫印迹法检测发现其抑制了细胞增殖。异种移植实验在体内也显示了类似结果。KIF20B是胰腺癌潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/0400fdc470e9/JO2021-5572402.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/1b031b921d88/JO2021-5572402.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/1e0bfb1fa260/JO2021-5572402.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/658a7dc8f5e6/JO2021-5572402.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/3cb47b75067a/JO2021-5572402.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/0400fdc470e9/JO2021-5572402.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/1b031b921d88/JO2021-5572402.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/1e0bfb1fa260/JO2021-5572402.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/658a7dc8f5e6/JO2021-5572402.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/3cb47b75067a/JO2021-5572402.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6c/8445734/0400fdc470e9/JO2021-5572402.005.jpg

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