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一种新型草药配方（WSY-1075）在非细菌性前列腺炎大鼠模型中的抗炎作用。

The Anti-Inflammatory Effects of a New Herbal Formula (WSY-1075) in a Nonbacterial Prostatitis Rat Model.

机构信息

Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

World J Mens Health. 2013 Aug;31(2):150-6. doi: 10.5534/wjmh.2013.31.2.150. Epub 2013 Aug 31.

DOI:10.5534/wjmh.2013.31.2.150
PMID:24044110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3770850/
Abstract

PURPOSE

The aim of this study was to investigate the anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model.

MATERIALS AND METHODS

Prostatitis was induced in male Wistar rats (n=32) by treatment with 17 beta-estradiol and dihydrotestosterone for 4 weeks. After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8). After 4 weeks of treatment, the prostatic proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-8) levels and histological findings were noted.

RESULTS

The ciprofloxacin and WSY-1075 treatment groups showed significantly decreased proinflammatory cytokine levels compared with the control group. Histologically, treatment with ciprofloxacin and WSY-1075 significantly suppressed the severity of prostatitis lesions compared with those in the control group. No differences in the proinflammatory cytokine levels or histologic findings were observed with the dose dependent treatment of WSY-1075.

CONCLUSIONS

The new herbal formula, WSY-1075, showed effective anti-inflammatory activities in the prostate and may be useful for the clinical treatment of nonbacterial prostatitis. Our findings suggest that WSY-1075 has a beneficial effect on the prevention and treatment of nonbacterial prostatitis.

摘要

目的

本研究旨在探讨一种新的草药配方（WSY-1075）在非细菌性前列腺炎大鼠模型中的抗炎作用。

材料与方法

雄性 Wistar 大鼠（n=32）经 17β-雌二醇和二氢睾酮处理 4 周，诱导前列腺炎。诱导前列腺炎后，大鼠随机分为四组治疗：对照组（n=8）、环丙沙星（n=8）、WSY-1075（100mg/kg）（n=8）和 WSY-1075（400mg/kg）（n=8）。治疗 4 周后，观察前列腺前炎性细胞因子（肿瘤坏死因子-α、白细胞介素[IL]-6 和 IL-8）水平和组织学发现。

结果

与对照组相比，环丙沙星和 WSY-1075 治疗组的前炎性细胞因子水平显著降低。组织学上，与对照组相比，环丙沙星和 WSY-1075 治疗显著抑制了前列腺炎病变的严重程度。WSY-1075 的剂量依赖性治疗对前炎性细胞因子水平或组织学发现无差异。

结论

新的草药配方 WSY-1075 对前列腺具有有效的抗炎活性，可能对非细菌性前列腺炎的临床治疗有用。我们的研究结果表明，WSY-1075 对预防和治疗非细菌性前列腺炎有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/7d4de44b05ee/wjmh-31-150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/09577249461e/wjmh-31-150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/530373074d45/wjmh-31-150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/0f195a3ca2cd/wjmh-31-150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/7d4de44b05ee/wjmh-31-150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/09577249461e/wjmh-31-150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/530373074d45/wjmh-31-150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/0f195a3ca2cd/wjmh-31-150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c51/3770850/7d4de44b05ee/wjmh-31-150-g004.jpg

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