瑞芬太尼联合七氟醚吸入麻醉对内镜下选择性静脉曲张断流术患者凝血功能及术后恢复的影响
Effect of remifentanil combined with sevoflurane inhalation anesthesia on coagulation function and postoperative recovery of patients undergoing endoscopic selective varices devascularization.
作者信息
Dai Maolin, Lv Pin, Hu Xiaojun, Zheng Binwu
机构信息
Department of Anesthesiology, Rongchang People's Hospital Chongqing City, China.
Department of Orthopedics, Rongchang People's Hospital Chongqing City, China.
出版信息
Am J Transl Res. 2021 Aug 15;13(8):9764-9770. eCollection 2021.
OBJECTIVE
To investigate the effect of remifentanil combined with sevoflurane inhalation anesthesia on coagulation function and postoperative recovery of patients undergoing endoscopic selective varices devascularization (ESVD).
METHODS
Altogether 116 patients undergoing ESVD in our hospital were randomly divided into two groups. The control group received propofol combined with remifentanil anesthesia, while the observation group received remifentanil combined with sevoflurane inhalation anesthesia.
RESULTS
There was no statistical difference in coagulation function indexes between the control group and the observation group (P>0.05), and the clinical anesthesia effect of the observation group was better (P<0.001). Five minutes after intubation, compared with the control group, the clinical stress response index was better (all P<0.001), the quality of anesthesia recovery was higher (all P<0.001), the heart rate was better after anesthesia (P<0.001), and the incidence of adverse reactions was higher (P<0.01) in the observation group.
CONCLUSION
Compared with remifentanil combined with propofol anesthesia, remifentanil combined with sevoflurane inhalation anesthesia for ESVD can effectively improve the clinical anesthesia effect, improve the quality of anesthesia recovery, and reduce stress reactions, but the incidence of adverse reactions is increased. Therefore the clinical application still needs to be strengthened.
目的
探讨瑞芬太尼联合七氟醚吸入麻醉对内镜下选择性静脉曲张断流术（ESVD）患者凝血功能及术后恢复的影响。
方法
将我院116例行ESVD的患者随机分为两组。对照组采用丙泊酚联合瑞芬太尼麻醉，观察组采用瑞芬太尼联合七氟醚吸入麻醉。
结果
对照组与观察组凝血功能指标比较，差异无统计学意义（P>0.05），观察组临床麻醉效果更佳（P<0.001）。插管后5分钟，观察组与对照组比较，临床应激反应指标更佳（均P<0.001），麻醉恢复质量更高（均P<0.001），麻醉后心率更佳（P<0.001），不良反应发生率更高（P<0.01）。
结论
与瑞芬太尼联合丙泊酚麻醉相比，瑞芬太尼联合七氟醚吸入麻醉用于ESVD可有效提高临床麻醉效果，改善麻醉恢复质量，减轻应激反应，但不良反应发生率增加。因此，仍需加强其临床应用。
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