卡马西平和丙戊酸钠对首次全身性发作癫痫患者疗效、认知功能及尿酸的影响
Effects of carbamazepine and sodium valproate on efficacy, cognitive function and uric acid in epileptic patients with first generalized seizure.
作者信息
Xiang Ruping, Xu Juan, Yu Huiyun, Chen Qiong, Huang Yujuan, Li Zhi, Yu Cheng, Cui Rong
机构信息
Department of Neurology, The Affiliated Changsha Hospital of Hunan Normal University Changsha 410006, Hunan, China.
Department of Rehabilitation Medicine, The Affiliated Changsha Hospital of Hunan Normal University Changsha 410006, Hunan, China.
出版信息
Am J Transl Res. 2021 Aug 15;13(8):9778-9783. eCollection 2021.
OBJECTIVE
To investigate the effects of carbamazepine and sodium valproate on efficacy, cognitive function and uric acid in epileptic patients with first generalized seizure.
METHODS
120 epilepsy patients with first generalized seizure who admitted to our hospital from March 2017 to March 2019, were selected and randomly divided into carbamazepine-group and sodium valproate-group, with 60 objects in each group. Both groups of patients received medication for one year. Subsequently, the changes in clinical efficacy, cognitive function, and blood uric acid of the two groups of patients 1 year after treatment were compared, and the correlation between blood uric acid and cognitive function was analyzed between the two groups.
RESULTS
The two groups had statistically insignificant difference in the total effective rate (). The cognitive function scores of the two groups after 6 months and 1 year of treatment were critically higher than those before treatment (), and the comparison of cognitive function and blood uric acid degree between groups before treatment, 6 months after treatment and 1 year after treatment had statistically insignificant difference (). There was a significant positive correlation between Mini-mental State Examination (MMSE) score of cognitive function and level of blood uric acid in patients with epilepsy (r=0.279, P=0.012).
CONCLUSION
Both carbamazepine and valproate can effectively improve the cognitive function of patients with first generalized seizure, and the two medications have similar clinical efficacy. Patient's blood uric acid level increases after treatment, and there is a affirmative relationship between blood uric acid level and cognitive function of patients.
目的
探讨卡马西平和丙戊酸钠对首次全面性发作癫痫患者疗效、认知功能及尿酸的影响。
方法
选取2017年3月至2019年3月我院收治的120例首次全面性发作癫痫患者，随机分为卡马西平组和丙戊酸钠组，每组60例。两组患者均接受为期一年的药物治疗。随后，比较两组患者治疗1年后临床疗效、认知功能及血尿酸的变化，并分析两组患者血尿酸与认知功能的相关性。
结果
两组总有效率差异无统计学意义（）。两组治疗6个月及1年后认知功能评分均显著高于治疗前（），治疗前、治疗6个月及治疗1年后组间认知功能及血尿酸程度比较差异无统计学意义（）。癫痫患者认知功能简易精神状态检查表（MMSE）评分与血尿酸水平呈显著正相关（r=0.279，P=0.012）。
结论
卡马西平和丙戊酸均可有效改善首次全面性发作癫痫患者的认知功能，两种药物临床疗效相似。治疗后患者血尿酸水平升高，血尿酸水平与患者认知功能呈正相关。
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