白金丸治疗伴有认知障碍的全身强直阵挛发作癫痫的临床疗效
Clinical efficacy of Baijin pills in the treatment of generalized tonic-clonic seizure epilepsy with cognitive impairment.
作者信息
Li Jing-Bo, Jiang Jing, Xue Lian, Zhao Shuai, Liu Hong-Quan
机构信息
Department of Neurology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu Province, China.
Department of Neurology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210000, Jiangsu Province, China.
出版信息
World J Psychiatry. 2024 Jun 19;14(6):938-944. doi: 10.5498/wjp.v14.i6.938.
BACKGROUND
The generalized tonic-clonic seizure (GTCS) is the most usual variety of epileptic seizure. It is mainly characterized by strong body muscle rigidity, loss of consciousness, a disorder of plant neurofunction, and significant damage to cognitive function. The effect of antiepileptic drugs on cognition should also be considered. At present, there is no effective treatment for patients with epilepsy, but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should, therefore, be considered for the therapy means of epilepsy with cognitive dysfunction.
AIM
To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive impairment.
METHODS
This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups (experimental and control) using random number table method. The control group was treated with sodium valproate, and the experimental group was Baijin pills and sodium valproate for three months. The frequency and duration of each seizure, the Montreal Cognitive Assessment Scale (MoCA), and the Quality of Life Rating Scale (QOLIE-31) were recorded before and after treatment.
RESULTS
There were 85 patients included (42 in the control group and 43 in the experimental group). After treatment, the seizure frequency in the experimental group was significantly reduced ( < 0.05), and seizure duration was shortened ( < 0.01). The total MoCA score in the experimental group significantly increased compared to before treatment ( < 0.01), and the sub-item scores, except naming and abstract generalization ability, significantly increased ( < 0.05), whereas the total MoCA score in the control group significantly decreased after treatment ( < 0.05). The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment ( < 0.01).
CONCLUSION
Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.
背景
全身强直-阵挛性发作（GTCS）是最常见的癫痫发作类型。其主要特征为全身肌肉强烈强直、意识丧失、自主神经功能紊乱以及认知功能严重受损。还应考虑抗癫痫药物对认知的影响。目前，癫痫患者尚无有效治疗方法，但中药对慢性病显示出显著疗效，且副作用较少，因此应考虑将其作为伴有认知功能障碍的癫痫的治疗手段。
目的
探讨白金丸治疗GTCS伴认知障碍患者的临床疗效。
方法
本前瞻性研究纳入2020年1月至2023年12月诊断为GTCS的患者，采用随机数字表法将其分为两组（试验组和对照组）。对照组用丙戊酸钠治疗，试验组用白金丸和丙戊酸钠治疗3个月。记录治疗前后每次发作的频率和持续时间、蒙特利尔认知评估量表（MoCA）以及生活质量评定量表（QOLIE-31）。
结果
共纳入85例患者（对照组42例，试验组43例）。治疗后，试验组发作频率显著降低（<0.05），发作持续时间缩短（<0.01）。试验组MoCA总分较治疗前显著升高（<0.01），除命名和抽象概括能力外的各分项得分均显著升高（<0.05），而对照组治疗后MoCA总分显著降低（<0.05）。试验组治疗后QOLIE-31评分较治疗前显著升高（<0.01）。
结论
白金丸对伴有认知功能障碍的癫痫有良好的临床疗效。
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