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靶向长链非编码 RNA CRNDE 逆转卵巢癌细胞株 CAOV3/R 的放射抵抗

Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE.

机构信息

Department of Radiotherapy, Gansu Tumor Hospital, 730050 Lanzhou, Gansu, China.

Gynecologic Oncology Department, Gansu Tumor Hospital, 730050 Lanzhou, Gansu, China.

出版信息

J Healthc Eng. 2021 Sep 8;2021:8556965. doi: 10.1155/2021/8556965. eCollection 2021.

DOI:10.1155/2021/8556965
PMID:34540189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8443391/
Abstract

Radiotherapy resistance is one of the key factors of poor prognosis of ovarian cancer clinical treatment. The search for key targets of ovarian cancer radiotherapy resistance has become a high priority. Long noncoding RNA plays an important role in tumor development. However, the key lncRNA in ovarian cancer radiotherapy resistance is not identified. Our finding that lncRNA CRNDE is highly expressed in the radiotherapy resistance cell line CAOV3/R drew our attention. Therefore, in this study, we targeted lncRNA CRNDE to analyze whether it is a key factor of radiotherapy resistance in ovarian cancer. Ultimately, we found that silencing lncRNA CRNDE could reverse CAOV3/R radiotherapy resistance, which would be a boon to clinical treatment.

摘要

放射抗拒是卵巢癌临床治疗预后不良的关键因素之一。寻找卵巢癌放射抗拒的关键靶点已成为当务之急。长链非编码 RNA 在肿瘤发生发展中发挥重要作用。然而，卵巢癌放射抗拒相关的关键 lncRNA 尚未明确。我们发现长链非编码 RNA CRNDE 在放射抗拒细胞系 CAOV3/R 中高表达，引起了我们的关注。因此，在本研究中，我们针对 lncRNA CRNDE 进行分析，以明确其是否为卵巢癌放射抗拒的关键因素。最终我们发现，沉默 lncRNA CRNDE 可逆转 CAOV3/R 的放射抗拒，这将有助于临床治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/8443391/ebb14d71c74f/JHE2021-8556965.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/8443391/9d0d087d1f54/JHE2021-8556965.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/8443391/ebb14d71c74f/JHE2021-8556965.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/8443391/9d0d087d1f54/JHE2021-8556965.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/8443391/ebb14d71c74f/JHE2021-8556965.002.jpg

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