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解析非阻塞性冠状动脉心肌梗死与抗磷脂综合征之间的关联

Unraveling the Association Between Myocardial Infarction of Nonobstructive Coronary Arteries and Antiphospholipid Syndrome.

作者信息

Ramjas Vishal, Jain Arpit, Lee Rholter Dave M, Fioni Fioni, Tawfik Nouran, Sandhu Osama, Hamid Pousette

机构信息

Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

出版信息

Cureus. 2021 Aug 8;13(8):e17002. doi: 10.7759/cureus.17002. eCollection 2021 Aug.

Abstract

The term "myocardial infarction with nonobstructive coronary arteries (MINOCA)" refers to a condition characterized by clinical signs and symptoms consistent with acute myocardial infarction (AMI) (as defined by the third universal definition of infarction) and coronary arteries that are angiographically normal or nearly normal. A prominent source of morbidity and mortality in patients with antiphospholipid syndrome (APS) is thrombotic events. To evaluate whether there is a relation between APS and MINOCA in this research, we did an extensive assessment of the existing research in this field. According to the data, APS was associated with microvascular thrombosis, aberrant lipid metabolism, hypertension, and abnormalities of the coagulation cascade, among other conditions. Based on the available data, we discovered evidence that suggests a relationship between MINOCA and APS patients. It is vital to raise awareness of this concern among the general public. Also required is the development and implementation of diagnostic and targeted treatment guidelines for patients with APS and MINOCA.

摘要

“非阻塞性冠状动脉心肌梗死(MINOCA)”一词指的是一种病症,其特征为具有与急性心肌梗死(AMI)(如梗死的第三个通用定义所界定)相符的临床体征和症状,且冠状动脉在血管造影上正常或近乎正常。抗磷脂综合征(APS)患者发病和死亡的一个主要原因是血栓形成事件。为了在本研究中评估APS与MINOCA之间是否存在关联,我们对该领域的现有研究进行了广泛评估。根据数据,APS与微血管血栓形成、脂质代谢异常、高血压以及凝血级联异常等情况有关。基于现有数据,我们发现了表明MINOCA与APS患者之间存在关联的证据。提高公众对这一问题的认识至关重要。此外,还需要制定并实施针对APS和MINOCA患者的诊断及靶向治疗指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b525/8423341/53a9ad942d99/cureus-0013-00000017002-i01.jpg

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