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木质素距离成为生物医学材料还有多远?

How far is Lignin from being a biomedical material?

作者信息

Sugiarto Sigit, Leow Yihao, Tan Chong Li, Wang Guan, Kai Dan

机构信息

Institute of Materials Research and Engineering (IMRE), ASTAR, 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634 Singapore.

Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore.

出版信息

Bioact Mater. 2021 Jun 26;8:71-94. doi: 10.1016/j.bioactmat.2021.06.023. eCollection 2022 Feb.

Abstract

Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant, antibacterial, anti-UV, and good biocompatibility. Natural lignin can be processed through several chemical processes. The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials. Thus, lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery, biosensors, bioimaging, 3D printing, tissue engineering, and dietary supplement additive. This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials. Thereafter, we also discuss on the challenges and outlook of utilizing lignin as a biomaterial.

摘要

木质素是一种用途广泛的生物质,具有许多不同的理想特性,如抗氧化、抗菌、抗紫外线以及良好的生物相容性。天然木质素可以通过多种化学方法进行加工。经过加工的木质素可以通过化学修饰转化为功能化木质素,以开发和增强生物材料。因此,木质素是各种生物材料应用的主要候选材料之一,如药物和基因递送、生物传感器、生物成像、3D打印、组织工程和膳食补充剂添加剂。本综述从新型可持续生物材料的角度介绍了开发和利用木质素的潜力。此后,我们还讨论了将木质素用作生物材料的挑战和前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31d0/8424518/21278c845db9/ga1.jpg

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