Huang Lifei, Hu Shuyang, Fu Ya-Nan, Wan Yan, Li Guofeng, Wang Xing
State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China.
J Mater Chem B. 2022 Dec 7;10(47):9735-9754. doi: 10.1039/d2tb02025d.
Nanocarriers can be used to deliver insoluble anticancer drugs to optimize therapeutic efficacy. However, the potential toxicity of nanocarriers cannot be ignored. Carrier-free nanodrugs are emerging safe drug delivery systems, which are composed of multiple components, such as drugs, bioactive molecules and functional ingredients, avoiding the usage of inert carrier materials and offering advantages that include high drug loading, low toxicity, synergistic therapy, versatile design, and easy surface functionalization. Therefore, how to design multicomponent carrier-free nanodrugs is becoming a priority. In this review, the common strategies for rapid construction of multicomponent carrier-free nanodrugs are briefly explored from the perspective of methodology. The properties of organic-organic, organic-inorganic and inorganic-inorganic multiple carrier-free nanosystems are analyzed according to wettability and in-depth understanding is provided. Further advances in the applications of multiple carrier-free nanodrugs are outlined in anticipation of grasping the intrinsic nature for the design and development of carrier-free nanodrugs.
纳米载体可用于递送不溶性抗癌药物以优化治疗效果。然而，纳米载体的潜在毒性不容忽视。无载体纳米药物是正在兴起的安全药物递送系统，它由多种成分组成，如药物、生物活性分子和功能成分，避免了惰性载体材料的使用，并具有高载药量、低毒性、协同治疗、设计多样和易于表面功能化等优点。因此，如何设计多组分无载体纳米药物正成为一个优先事项。在这篇综述中，从方法学的角度简要探讨了快速构建多组分无载体纳米药物的常见策略。根据润湿性分析了有机-有机、有机-无机和无机-无机多无载体纳米系统的性质，并提供了深入的理解。展望了多组分无载体纳米药物应用的进一步进展，以期掌握无载体纳米药物设计和开发的内在本质。
