Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.
Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
PLoS One. 2021 Sep 20;16(9):e0257627. doi: 10.1371/journal.pone.0257627. eCollection 2021.
Most research into the management of pelvic inflammatory disease (PID) is in younger women and focuses on sexually transmitted pathogens such as N. gonorrhoeae or C. trachomatis. Non-sexually transmitted bacterial pathogens and PID in older women are rarely examined. The objective of this study is to explore cervical culture pathogens in women of different age groups in a medical center in eastern Taiwan.
We enrolled patients whose medical records were diagnosed with PID (ICD-9-CM 614.0 [N70.01-03], 614.1[N70.11-13], 614.9 [N73.5, N73.9]) at our hospital from October 2014 to March 2020. Patients were divided into three groups according to age: the age <25 years, age 25-44 years, and the ≥ 45 years group. Chi-square test, ANOVA and logistic regression were used for statistical analysis. In subgroup analysis, endocervical pathogens were further stratified into vaginal, respiratory, enteric, skin, oral, and other.
A total of 96 patients were included in the study. There were 31 patients in the age ≥ 45 years group, 52 patients in the age 25-44 years group, and 13 patients in the age <25 years group. Vagina and enteric pathogens were the most common pathogens among all groups. The isolated respiratory and other pathogens were more in the age ≥ 45 years group than in the other two groups. Prevotella bivia was more common in the age <25 years and 25-44 years groups.
This may be due to different pathogeneses of PID in the age ≥ 45 years patients. Our study can be used as a reference for antibiotic choice of non-sexually transmitted PID and to prevent long-term sequelae of PID.
大多数关于盆腔炎（PID）管理的研究都集中在年轻女性身上，并且侧重于淋病奈瑟菌或沙眼衣原体等性传播病原体。年龄较大的女性中的非性传播细菌病原体和 PID 很少被研究。本研究旨在探讨台湾东部一家医疗中心不同年龄组女性的宫颈培养病原体。
我们招募了 2014 年 10 月至 2020 年 3 月期间在我院就诊且病历诊断为 PID（ICD-9-CM 614.0[N70.01-03]、614.1[N70.11-13]、614.9[N73.5、N73.9]）的患者。根据年龄将患者分为三组：年龄<25 岁、年龄 25-44 岁和年龄≥45 岁组。采用卡方检验、方差分析和逻辑回归进行统计分析。在亚组分析中，进一步将宫颈病原体分为阴道、呼吸道、肠道、皮肤、口腔和其他。
共纳入 96 例患者。年龄≥45 岁组 31 例，年龄 25-44 岁组 52 例，年龄<25 岁组 13 例。所有组中最常见的病原体均为阴道和肠道病原体。年龄≥45 岁组分离出的呼吸道和其他病原体比其他两组更多。普雷沃氏菌属在年龄<25 岁和 25-44 岁组中更为常见。
这可能是由于年龄≥45 岁患者 PID 的不同病原体。我们的研究可以作为非性传播 PID 抗生素选择的参考，并预防 PID 的长期后遗症。
