Department of Physiology, Faculty of Medicine, Benha University, Benha City, Egypt.
Department of Basic Medical Sciences, Faculty of Medicine, Hashemite University, Zarqa, Jordan.
Arch Physiol Biochem. 2024 Feb;130(1):87-95. doi: 10.1080/13813455.2021.1975758. Epub 2021 Sep 20.
Inflammatory and immune pathways play a crucial role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Sitagliptin blocks the dipeptidyl peptidase-4 (DPP-4) enzyme, mechanisms that alter inflammatory pathways and the innate immune system, and by which Sitagliptin affects the pathogenesis of NAFLD weren't previously discussed.
This study aims to understand the interaction between Sitagliptin and innate immune response in order to meliorate NAFLD.
Thirty- two Wistar male albino rats were categorised into four groups. Rats have received a standard diet or a high-fat diet either with or without Sitagliptin. Serum HMGB1, protein and mRNA expressions of hepatic TLR4 and NF-κB, inflammatory cytokines, and histopathological changes were analysed.
An ameliorative action of Sitagliptin in NAFLD was demonstrated via decreasing HMGB1-mediated TLR4/NF-κB signalling in order to suppress inflammation and reduce insulin resistance.
Sitagliptin may in fact prove to be a beneficial therapeutic intervention in NAFLD.
炎症和免疫途径在非酒精性脂肪性肝病（NAFLD）的病理生理学中起着至关重要的作用。西他列汀阻断二肽基肽酶-4（DPP-4）酶，该酶改变炎症途径和先天免疫系统，西他列汀通过何种机制影响 NAFLD 的发病机制尚未被讨论。
本研究旨在了解西他列汀与先天免疫反应之间的相互作用，以改善 NAFLD。
将 32 只雄性 Wistar 白化大鼠分为四组。大鼠给予标准饮食或高脂肪饮食，同时给予或不给予西他列汀。分析血清高迁移率族蛋白 B1（HMGB1）、肝 TLR4 和 NF-κB 的蛋白和 mRNA 表达、炎症细胞因子以及组织病理学变化。
西他列汀通过降低 HMGB1 介导的 TLR4/NF-κB 信号转导，从而抑制炎症和减轻胰岛素抵抗，对 NAFLD 具有改善作用。
西他列汀实际上可能成为治疗 NAFLD 的有益治疗干预措施。
