Can DXA image-based deep learning model predict the anisotropic elastic behavior of trabecular bone?

3D image-based finite element (FE) and bone volume fraction (BV/TV)/fabric tensor modeling techniques are currently used to determine the apparent stiffness tensor of trabecular bone for assessing its anisotropic elastic behavior. Inspired by the recent success of deep learning (DL) techniques, we hypothesized that DL modeling techniques could be used to predict the apparent stiffness tensor of trabecular bone directly using dual-energy X-ray absorptiometry (DXA) images. To test the hypothesis, a convolutional neural network (CNN) model was trained and validated to predict the apparent stiffness tensor of trabecular bone cubes using their DXA images. Trabecular bone cubes obtained from human cadaver proximal femurs were used to obtain simulated DXA images as input, and the apparent stiffness tensor of the trabecular cubes determined by using micro-CT based FE simulations was used as output (ground truth) to train the DL model. The prediction accuracy of the DL model was evaluated by comparing it with the micro-CT based FE models, histomorphometric parameter based multiple linear regression models, and BV/TV/fabric tensor based multiple linear regression models. The results showed that DXA image-based DL model achieved high fidelity in predicting the apparent stiffness tensor of trabecular bone cubes (R = 0.905-0.973), comparable to or better than the histomorphometric parameter based multiple linear regression and BV/TV/fabric tensor based multiple linear regression models, thus supporting the hypothesis of this study. The outcome of this study could be used to help develop DXA image-based DL techniques for clinical assessment of bone fracture risk.