State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
J Biomed Nanotechnol. 2021 Aug 1;17(8):1627-1634. doi: 10.1166/jbn.2021.3123.
The development of drug-resistant bacteria has become a public health problem, among which methicillin-resistant (MRSA) leads to various life-threatening diseases. Graphene oxide (GO) is a two-dimensional nanomaterial with potential in the anti-MRSA treatment. This study prepared GO nanosheets with fixed lamellar size, investigated its antibacterial activity against MRSA, and analyzed the related antibacterial mechanisms. We found that the fabrication of GO with stable dispersion was workable. Furthermore, such GO had superior antibacterial performance against MRSA at low concentrations with the dose-dependent anti-MRSA effect. The GO-MRSA interaction also provided fundamental support for the antibacterial mechanisms with cleavage and encapsulation effects. In conclusion, GO nanosheets may be a promising antimicrobial agent against MRSA.
耐药菌的发展已经成为一个公共卫生问题，其中耐甲氧西林金黄色葡萄球菌（MRSA）导致了各种危及生命的疾病。氧化石墨烯（GO）是一种具有抗 MRSA 治疗潜力的二维纳米材料。本研究制备了具有固定层状尺寸的 GO 纳米片，研究了其对 MRSA 的抗菌活性，并分析了相关的抗菌机制。我们发现，制备具有稳定分散性的 GO 是可行的。此外，这种 GO 在低浓度下对 MRSA 具有优异的抗菌性能，且具有剂量依赖性的抗 MRSA 作用。GO 与 MRSA 的相互作用也为具有裂解和包裹作用的抗菌机制提供了基础支持。总之，GO 纳米片可能是一种有前途的抗 MRSA 抗菌剂。
