雄激素使用与公共卫生关切和 COVID-19 重症风险增加相关。
Public health concerns and increased risk of severe COVID-19 disease through androgen use.
机构信息
Institute of Sport, Nursing and Allied Health, University of Chichester, Chichester, West Sussex, UK.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2021 Dec 1;28(6):625-629. doi: 10.1097/MED.0000000000000674.
PURPOSE OF REVIEW
Given governmental policy responses to the COVID-19 pandemic include various foci on establishing preventive measures to increase the health and constitution of populations (i.e. through renewed efforts to tackle obesity), the use of androgens in a recreational manner requires attention because of existing medical evidence related to their role in immunosuppression.
RECENT FINDINGS
Whilst a broad body of work exists that outlines the mechanisms that underpin COVID-19 and public health responses, as well as the use of androgens in both recreational and medicinal contexts, the recent nature of the disease has left an area requiring greater investigation and clarification. There is emerging literature that highlights the potential complications that existing androgens use may bring to those infected with COVID-19, as well as the start of empirical evidence detailing this.
SUMMARY
In this article, we outline the latest viewpoints and literature related to how the use of androgens may contribute to less robust immunoresponses.
综述目的：鉴于各国政府对 COVID-19 大流行的政策应对措施包括各种侧重于建立预防措施以提高人群健康和体质（即通过新的努力来解决肥胖问题）的重点，因此需要关注娱乐性使用雄激素的问题，因为现有医学证据表明它们在免疫抑制方面的作用。
最近的发现：虽然已经有大量的工作阐明了 COVID-19 及其公共卫生应对措施的基础机制，以及在娱乐和医疗背景下使用雄激素的情况，但由于该疾病的新近出现，仍有一些领域需要进一步调查和澄清。越来越多的文献强调了现有的雄激素使用可能给感染 COVID-19 的人带来的潜在并发症，以及开始详细描述这方面经验证据的情况。
总结：本文概述了有关雄激素使用如何可能导致免疫反应减弱的最新观点和文献。
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