State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
College of Medicine, Guilin Medical University, Guilin 541199, China.
J Org Chem. 2021 Oct 1;86(19):13381-13387. doi: 10.1021/acs.joc.1c01489. Epub 2021 Sep 21.
Five dimeric alkaloids, named erythrivarines J-N, were isolated from the barks of L. (Fabaceae). The erythrivarines J-L featured a 6/6/5/6/6/5/6/6/6 ring system and super conjugated double bond systems, causing intense color from blue to wine red, while erythrivarines M-N looked orange. The structures of the isolated compounds were elucidated by 1D and 2D NMR experiments combined with MS and confirmed by the X-ray crystal diffraction technique. The performed bioassay using HEI-OC-1 cells revealed neuroprotective properties of erythrivarine N against the hearing loss causing antibiotics, neomycin.
从 L.（豆科）树皮中分离得到五个二聚生物碱，命名为 erythrivarines J-N。erythrivarines J-L 具有 6/6/5/6/6/5/6/6/6 环系统和超共轭双键系统，导致颜色从蓝色到酒红色的强烈变化，而 erythrivarines M-N 呈现橙色。通过 1D 和 2D NMR 实验结合 MS 确定了分离化合物的结构，并通过 X 射线晶体衍射技术得到了证实。使用 HEI-OC-1 细胞进行的生物测定表明，erythrivarine N 对导致听力损失的抗生素新霉素具有神经保护作用。
