来自中国粗榧种子的对映体三尖杉生物碱
Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri.
作者信息
Yu Guang-Xing, Wu Jing, Shi Bao-Bao, Bao Mei-Fen, Cai Xiang-Hai
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100039, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2022 Jul 1;12(1):24. doi: 10.1007/s13659-022-00344-1.
Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.
从中国粗榧种子中分离出5种未描述的生物碱以及27种已知生物碱。基于包括一维和二维核磁共振、质谱和计算的电子圆二色谱等光谱数据阐明了新结构。其中，(+)-乙酰头状粗榧碱C是一种对映体头状粗榧生物碱。所进行的生物测定表明，这些生物碱对癌细胞无细胞毒性，在HEI-OC-1细胞模型中无神经保护特性。
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