Larijani Banafshé, Pytowski Lior, Vaux David J
Centre for Therapeutic Innovation & Cell Biophysics Laboratory, Department of Pharmacy and Pharmacology & Department of Physics, University of Bath, Bath BA2 7AY, UK.
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Biochim Biophys Acta Biomembr. 2022 Feb 1;1864(1):183780. doi: 10.1016/j.bbamem.2021.183780. Epub 2021 Sep 20.
The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.
分子类别脂质与通过内膜进行的细胞通讯途径普遍分离，导致在解读细胞信号传导机制时过度简化并产生误解。信号转导和蛋白质激活机制要求将蛋白质靶向具有特定局部形态和动力学的膜性区室，而这些形态和动力学取决于其脂质组成。许多翻译后事件决定细胞行为，若没有膜性区室的积极作用，这些事件会导致信号通路的各种失调。我们使用诸如雷帕霉素类似物二聚化等工具，总结了相互关联的磷酸肌醇脂质及其衍生物二酰基甘油在调节核膜生物发生及其他亚细胞区室（如核内质网）中的结构作用和信号传导方面的关键发现。
