Shrestha H K, Katwal P C
Department of Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
Kathmandu Univ Med J (KUMJ). 2017 Apr-Jun;17(58):146-149.
Background Diabetic peripheral neuropathy (DPN) is a well-known microvascular complication of type 2 diabetes mellitus (T2DM) attributed to chronic hyperglycemia, and is defined as the presence of peripheral nerve dysfunction in patients with diabetes after exclusion of other causes. Objective To determine the prevalence and risk factors of Diabetic Peripheral Neuropathy among type 2 diabetes mellitus patients. Method A cross sectional study was carried out in a University Teaching Hospital. Type 2 diabetes mellitus patients with diabetes duration of more than 6 months were recruited. Michigan Neuropathy Screening Instrument Scoring was used to diagnose Diabetic Peripheral Neuropathy. Result Among a total of 160 patients who were enrolled, 61 (38.1%) had diabetic peripheral neuropathy and 26 (16%) had diabetic peripheral neuropathy within 1 year of being diagnosed with diabetes. Mean Diabetes duration was 5.56 years and mean age was 57.32 years, with 90 (56%) of the participants being female. The mean HbA1c was 8.33%. Among them 25% of the participants were alcoholics and 30% were smoker. No statistically significant risk factors are evident on multivariate analysis. Conclusion Diabetic peripheral neuropathy was found to be highly prevalent in patients with type 2 diabetes including the patients with relatively shorter diabetes duration. This finding warrants the need of improving the preventive measures and quality of care related to foot complication among patients with type 2 diabetes.
糖尿病周围神经病变（DPN）是2型糖尿病（T2DM）一种广为人知的微血管并发症，归因于慢性高血糖，其定义为排除其他病因后糖尿病患者存在周围神经功能障碍。目的：确定2型糖尿病患者中糖尿病周围神经病变的患病率及危险因素。方法：在一所大学教学医院开展一项横断面研究。招募糖尿病病程超过6个月的2型糖尿病患者。采用密歇根神经病变筛查量表评分诊断糖尿病周围神经病变。结果：在总共纳入的160例患者中，61例（38.1%）患有糖尿病周围神经病变，26例（16%）在确诊糖尿病1年内发生糖尿病周围神经病变。平均糖尿病病程为5.56年，平均年龄为57.32岁，90例（56%）参与者为女性。平均糖化血红蛋白（HbA1c）为8.33%。其中25%的参与者为酗酒者，30%为吸烟者。多因素分析未发现明显的统计学显著危险因素。结论：发现糖尿病周围神经病变在2型糖尿病患者中高度流行，包括糖尿病病程相对较短的患者。这一发现表明有必要改善2型糖尿病患者足部并发症的预防措施及护理质量。
