Romero-Piffiguer M, Ferro M E, Riera C M
Departmento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Jpn J Med Sci Biol. 1987 Oct-Dec;40(5-6):175-85. doi: 10.7883/yoken1952.40.175.
The aim of this report is to describe the influence of the way of infection with 3 X 10(3) trophozoites of Toxoplasma gondii on the auto- and heteroimmune responses of rats immunized with chemically modified rat male accessory glands (MRAG) and human serum albumin (HSA) 6 and 36 days after infection. The delayed hypersensitivity (DTH) response to MRAG was potentiated in rats infected in thymus proximity (p less than 0.02) when compared with rats only immunized. The parasites introduced intraperitoneally did not modify the cellular autoimmune response. The titers of hemagglutinating antibodies to MRAG were increased in animals infected by both ways (p less than 0.05). The response to HSA did not show significant difference between the infected and uninfected rats. Thymic involution and proliferation of lymphocytes and plasma cells were observed at 6 and 52 days post-infection only in rats infected in thymus proximity (p less than 0.05). A correlation between the potentiation of cellular autoimmune response and the injection of parasites in thymus proximity was observed.
本报告旨在描述以3×10³个刚地弓形虫滋养体的感染方式，对感染后6天和36天用化学修饰的大鼠雄性副腺（MRAG）和人血清白蛋白（HSA）免疫的大鼠自身免疫和异种免疫反应的影响。与仅免疫的大鼠相比，在胸腺附近感染的大鼠对MRAG的迟发型超敏反应（DTH）增强（p<0.02）。经腹腔注射的寄生虫未改变细胞自身免疫反应。两种感染方式的动物中，针对MRAG的血凝抗体滴度均升高（p<0.05）。感染组和未感染组大鼠对HSA的反应无显著差异。仅在胸腺附近感染的大鼠中，感染后6天和52天观察到胸腺退化以及淋巴细胞和浆细胞增殖（p<0.05）。观察到细胞自身免疫反应增强与在胸腺附近注射寄生虫之间存在相关性。
