Morita M
Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
Jpn J Physiol. 1987;37(6):1019-29. doi: 10.2170/jjphysiol.37.1019.
To analyze the change in blood volume after intestinal absorption, circulating blood volume was continuously monitored in rats after infusion of various solutions into the small intestine. Arterial and venous catheters were connected to a system for continuous monitoring of blood volume by the dilution method using 51Cr-labeled erythrocytes. Test solutions (tap water, 0.45, 0.9, 1.8% NaCl, 0.45% NaCl with 2% glucose, and 5% glucose) were infused at a rate of 1 ml/100 g body wt. for 10 min through a duodenal catheter. After the infusion, blood volume increased except in the 1.8% NaCl group, which showed a transient decrease in blood volume by about 10%. The rate of blood volume increase was highest in the 0.45% NaCl with 2% glucose group and lowest in the 1.8% NaCl group. The retention ratio of infused solution in the vascular space was almost identical among the groups and was about 22%. These results indicate that the rate of increase in blood volume after intestinal administration of fluid is modified by the osmolality of the fluid and Na-glucose co-transport, whereas the retention ratio of the infused fluid in blood is constant.
为分析肠道吸收后血容量的变化，在向大鼠小肠内输注各种溶液后，连续监测其循环血容量。将动脉和静脉导管连接到一个使用51Cr标记红细胞的稀释法连续监测血容量的系统。通过十二指肠导管以1 ml/100 g体重的速率输注测试溶液（自来水、0.45%、0.9%、1.8%氯化钠、含2%葡萄糖的0.45%氯化钠和5%葡萄糖）10分钟。输注后，除1.8%氯化钠组血容量短暂下降约10%外，其他组血容量均增加。血容量增加速率在含2%葡萄糖的0.45%氯化钠组最高，在1.8%氯化钠组最低。各实验组血管内输注溶液的留存率几乎相同，约为22%。这些结果表明，肠道给予液体后血容量的增加速率受液体渗透压和钠-葡萄糖共转运的影响，而输注液体在血液中的留存率是恒定的。
