Department of Hepatobiliary Surgery, Dongfang Hospital, Xiamen University, No.156, West Second Ring North Road, Gulou District, Fuzhou, People's Republic of China.
Department of Intensive Care Unit, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Sci Rep. 2021 Sep 21;11(1):18766. doi: 10.1038/s41598-021-98260-w.
Throughout the world, esophageal cancer patients had a greater suicidal risk compared with ordinary people. Thus, we aimed to affirm suicide rates, standardized mortality rates, and underlying suicide-related risk factors of esophageal cancer patients. Patients suffering esophageal cancer were chosen from the Surveillance, Epidemiology, and End Results repository in 1975-2016. Suicide rates as well as standardized mortality rates in the patients were measured. Univariable and multivariable Cox regression had been adopted for establishing the latent suicide risk factors among patients suffering esophageal cancer. On multivariable Cox regression, gender (male vs. female, HR: 6.37), age of diagnosis (70-105 vs. 0-55, HR: 2.69), marital status, race (white race vs. black race, HR: 6.64; American Indian/Alaska Native, Asian/Pacific Islander vs. black race, HR: 8.60), histologic Grade (Grade III vs. Grade I, HR: 2.36), no surgery performed (no/unknown vs. yes, HR: 2.01), no chemotherapy performed were independent risk factors related to suicide in patients suffering esophageal cancer. Male sex, the older age, unmarried state, non-black race, histologic Grade III, no surgery performed, no chemotherapy performed were strongly related to suicide in patients suffering esophageal cancer.
在全球范围内，食管癌患者的自杀风险高于普通人。因此，我们旨在确定食管癌患者的自杀率、标准化死亡率和潜在的自杀相关危险因素。我们从 1975 年至 2016 年的监测、流行病学和最终结果数据库中选择了患有食管癌的患者。测量了患者的自杀率和标准化死亡率。采用单变量和多变量 Cox 回归来确定食管癌患者的潜在自杀风险因素。在多变量 Cox 回归中，性别（男性与女性，HR：6.37）、诊断年龄（70-105 岁与 0-55 岁，HR：2.69）、婚姻状况、种族（白种人与黑种人，HR：6.64；美国印第安人/阿拉斯加原住民、亚洲/太平洋岛民与黑种人，HR：8.60）、组织学分级（III 级与 I 级，HR：2.36）、未行手术（无/未知与是，HR：2.01）、未行化疗是与食管癌患者自杀相关的独立危险因素。男性、年龄较大、未婚、非黑种人、组织学分级 III 级、未行手术、未行化疗与食管癌患者自杀密切相关。
