Indracanti Meera, Berhane Nega, Minyamer Tigist
Institute of Biotechnology, University of Gondar, Gondar, Ethiopia.
Cancer Manag Res. 2021 Sep 14;13:7149-7163. doi: 10.2147/CMAR.S326544. eCollection 2021.
Human papillomavirus (HPV) infections are sexually transmitted and most frequently associated with cervical cancer in women, but they are also a public health concern in men. There is rising evidence that HPV's role in other cancers, such as anal, vulva, vaginal, penis, head, and neck cancers. The present study aimed to understand the factors associated with HPV and cervical cancer knowledge levels of university students before and after an educational intervention.
An Institutional-based cross-sectional study was conducted from October to November 2018. A total of 638 study participants were selected using a simple random multistage sampling technique. A pretested questionnaire was used, consolidated the data, and analyzed with SPSS version 23. Bivariate and multivariate logistic regression analyses were performed to identify which variables were associated with the knowledge levels.
Six hundred thirty-eight study participants with a 100% response rate, and the mean age was 21.07 years (±SD, 1.96). Initial awareness of various broad categories was 4.09, and after the intervention, it increased to 23.4, with an average increase of 19.31 at 99% CI, p≤0.001 significance level. Before the educational intervention, students with <21 years of age [6.16, 95% CI: (2.21-17.18)] and ≤2.5 CGPA [3.44, 95% CI: (1.51-7.81)] were less knowledgeable over other counterparts. After educational intervention, the year of study was significantly associated with increased knowledge of overall and different broad categories of cervical cancer and HPV. Year of study, 1st-year students [AOR: 0.27, 95% CI: (0.14-0.51)] over third years and above are less knowledgeable. First-year students and CGPA ≤2.5 were less improved awareness over others.
The educational intervention improved more than fourfold increase knowledge on cervical cancer and HPV, and the year of study was a key factor associated with overall improvement. This study suggests that educational intervention effectively strengthens our understanding of the spread of HPV and cervical cancer disease burden.
人乳头瘤病毒（HPV）感染通过性传播，在女性中最常与宫颈癌相关，但在男性中也是一个公共卫生问题。越来越多的证据表明HPV在其他癌症中也发挥作用，如肛门癌、外阴癌、阴道癌、阴茎癌、头颈癌。本研究旨在了解教育干预前后大学生HPV和宫颈癌知识水平的相关因素。
2018年10月至11月进行了一项基于机构的横断面研究。使用简单随机多阶段抽样技术共选取了638名研究参与者。采用经过预测试的问卷，汇总数据并使用SPSS 23版进行分析。进行二元和多元逻辑回归分析以确定哪些变量与知识水平相关。
638名研究参与者的回复率为100%，平均年龄为21.07岁（±标准差，1.96）。各类别的初始知晓率为4.09，干预后提高到23.4，在99%置信区间平均提高了19.31，p≤0.001显著水平。在教育干预前，年龄<21岁的学生[6.16，95%置信区间：（2.21 - 17.18）]和CGPA≤2.5的学生[3.44，95%置信区间：（1.51 - 7.81）]比其他学生知识更少。教育干预后，学习年份与宫颈癌和HPV总体及不同类别知识的增加显著相关。学习年份方面，一年级学生[AOR：0.27，95%置信区间：（0.14 - 0.51）]比三年级及以上学生知识更少。一年级学生和CGPA≤2.5的学生的知晓率提高幅度低于其他学生。
教育干预使宫颈癌和HPV知识增加了四倍多，学习年份是与总体改善相关的关键因素。本研究表明教育干预有效增强了我们对HPV传播和宫颈癌疾病负担的理解。
