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自闭症谱系障碍个体中的新冠病毒疫苗接种:一项基于人群的研究。

COVID-19 vaccination among individuals with autism spectrum disorder: A population-based study.

作者信息

Weinstein Orly, Krieger Israel, Cohen Arnon Dov, Tzur Bitan Dana

机构信息

Hospitals Division, Clalit Health Services, Tel Aviv, Israel.

Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

出版信息

Res Autism Spectr Disord. 2021 Nov;89:101865. doi: 10.1016/j.rasd.2021.101865. Epub 2021 Sep 17.

Abstract

BACKGROUND

Individuals with autistic spectrum disorder (ASD) are more susceptible to COVID-19 morbidity and should therefore be prioritized for vaccination. Although individuals with neurodevelopmental disabilities are given some priority in Israel, it is unclear to what extent individuals with ASD are being vaccinated relative to that of the general population. This study was aimed to assess vaccination prevalence among individuals with ASD.

METHOD

Individuals with ASD, and age- and sex-matched controls (total = 11,080), were assessed for prevalence of COVID-19 vaccination by February 2021, approximately a month and a half after the national vaccination distribution plan was launched in Israel. Data were obtained from the database of Clalit Health Services (CHS), the largest healthcare organization in Israel.

RESULTS

Individuals with ASD were more likely to be vaccinated for COVID-19 ( = 2.55, 95 % 2.35-2.75, < .001) across both sexes, but only in the 16-20 ( = 2.04, 95 % 1.79-2.32, < .001) and 21-40 ( = 3.95, 95 % 3.52-4.43, < .001) age groups. After adjusting for chronic illnesses, ASD remained significant in predicting the uptake of COVID-19 vaccination.

CONCLUSIONS

Efforts to prioritize ASD patients may improve vaccination prevalence among individuals with ASD, especially among younger individuals. Healthcare providers worldwide should therefore consider prioritization policies so as to increase vaccination rates among this vulnerable population.

摘要

背景

自闭症谱系障碍(ASD)患者更容易感染新冠病毒,因此应优先接种疫苗。尽管以色列给予神经发育障碍患者一定的优先待遇,但相对于普通人群,ASD患者的疫苗接种程度尚不清楚。本研究旨在评估ASD患者的疫苗接种率。

方法

对ASD患者以及年龄和性别匹配的对照组(共11,080人)进行评估,以确定截至2021年2月(以色列全国疫苗接种分配计划启动约一个半月后)新冠疫苗接种率。数据来自以色列最大的医疗保健机构克拉利特医疗服务公司(Clalit Health Services,CHS)的数据库。

结果

无论男女,ASD患者接种新冠疫苗的可能性更高( = 2.55,95%置信区间2.35 - 2.75, <.001),但仅在16 - 20岁( = 2.04,95%置信区间1.79 - 2.32, <.001)和21 - 40岁( = 3.95,95%置信区间3.52 - 4.43, <.001)年龄组中如此。在对慢性病进行调整后,ASD在预测新冠疫苗接种情况方面仍然具有显著意义。

结论

优先考虑ASD患者的措施可能会提高ASD患者的疫苗接种率,尤其是在年轻患者中。因此,全球医疗保健提供者应考虑制定优先政策,以提高这一弱势群体的疫苗接种率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4dc/8445801/6e8d75b5d9cd/gr1_lrg.jpg

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